Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 2165..2699 Replicon plasmid new_pCD
Accession NC_010157
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag YPANGOLA_RS21995 Protein ID WP_002213360.1
Coordinates 2165..2464 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9ZGW3
Locus tag YPANGOLA_RS22000 Protein ID WP_002224342.1
Coordinates 2457..2699 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPANGOLA_RS21980 73..717 + 645 Protein_0 IS3 family transposase -
YPANGOLA_RS21985 780..1172 - 393 WP_002213403.1 type III secretion system chaperone SycE/YerA -
YPANGOLA_RS21990 1366..2025 + 660 WP_002229754.1 type III secretion system effector GTPase activator YopE -
YPANGOLA_RS21995 2165..2464 - 300 WP_002213360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YPANGOLA_RS22000 2457..2699 - 243 WP_002224342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
YPANGOLA_RS24525 2865..3157 - 293 Protein_5 IS6 family transposase -
YPANGOLA_RS25465 3243..3416 + 174 WP_002213357.1 hypothetical protein -
YPANGOLA_RS25285 3565..3801 - 237 WP_154020274.1 hypothetical protein -
YPANGOLA_RS22010 3961..4926 - 966 WP_002213354.1 ParB/RepB/Spo0J family plasmid partition protein -
YPANGOLA_RS22015 4923..6089 - 1167 WP_002220902.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yadA / yadA / sycH 1..68190 68190
- flank IS/Tn - - 232..717 485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(5-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T22575 WP_002213360.1 NC_010157:c2464-2165 [Yersinia pestis Angola]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T22575 NC_010157:c2464-2165 [Yersinia pestis Angola]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8865.15 Da        Isoelectric Point: 6.4781

>AT22575 WP_002224342.1 NC_010157:c2699-2457 [Yersinia pestis Angola]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT22575 NC_010157:c2699-2457 [Yersinia pestis Angola]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q663N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NQY6

References