Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4854285..4854801 Replicon chromosome
Accession NZ_CP087629
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02341

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LMH53_RS23955 Protein ID WP_002886902.1
Coordinates 4854285..4854569 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH53_RS23960 Protein ID WP_002886901.1
Coordinates 4854559..4854801 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH53_RS23930 (LMH53_23930) 4849769..4850032 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LMH53_RS23935 (LMH53_23935) 4850162..4850335 + 174 WP_002886906.1 hypothetical protein -
LMH53_RS23940 (LMH53_23940) 4850338..4851081 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH53_RS23945 (LMH53_23945) 4851438..4853576 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LMH53_RS23950 (LMH53_23950) 4853817..4854281 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH53_RS23955 (LMH53_23955) 4854285..4854569 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH53_RS23960 (LMH53_23960) 4854559..4854801 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH53_RS23965 (LMH53_23965) 4854879..4856789 - 1911 WP_004152270.1 PRD domain-containing protein -
LMH53_RS23970 (LMH53_23970) 4856812..4857966 - 1155 WP_002886900.1 lactonase family protein -
LMH53_RS23975 (LMH53_23975) 4858032..4858772 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T225744 WP_002886902.1 NZ_CP087629:c4854569-4854285 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225744 NZ_CP121298:559521-560006 [Salmonella enterica subsp. enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225744 WP_002886901.1 NZ_CP087629:c4854801-4854559 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225744 NZ_CP121298:559246-559533 [Salmonella enterica subsp. enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References