Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4138302..4138921 Replicon chromosome
Accession NZ_CP087629
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02341

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LMH53_RS20520 Protein ID WP_002892050.1
Coordinates 4138703..4138921 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LMH53_RS20515 Protein ID WP_002892066.1
Coordinates 4138302..4138676 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH53_RS20505 (LMH53_20505) 4133454..4134647 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LMH53_RS20510 (LMH53_20510) 4134670..4137816 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LMH53_RS20515 (LMH53_20515) 4138302..4138676 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LMH53_RS20520 (LMH53_20520) 4138703..4138921 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LMH53_RS20525 (LMH53_20525) 4139080..4139646 + 567 WP_002892030.1 maltose O-acetyltransferase -
LMH53_RS20530 (LMH53_20530) 4139618..4139758 - 141 WP_004147370.1 hypothetical protein -
LMH53_RS20535 (LMH53_20535) 4139779..4140249 + 471 WP_002892026.1 YlaC family protein -
LMH53_RS20540 (LMH53_20540) 4140224..4141675 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LMH53_RS20545 (LMH53_20545) 4141776..4142474 + 699 WP_002892021.1 GNAT family protein -
LMH53_RS20550 (LMH53_20550) 4142471..4142611 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LMH53_RS20555 (LMH53_20555) 4142611..4142874 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225742 WP_002892050.1 NZ_CP087629:4138703-4138921 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T225742 NZ_CP121298:c157818-157507 [Salmonella enterica subsp. enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT225742 WP_002892066.1 NZ_CP087629:4138302-4138676 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT225742 NZ_CP121298:c157506-157216 [Salmonella enterica subsp. enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References