Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2713292..2714880 Replicon chromosome
Accession NZ_CP087629
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02341

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag LMH53_RS13430 Protein ID WP_004199851.1
Coordinates 2713292..2714614 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LMH53_RS13435 Protein ID WP_002904790.1
Coordinates 2714614..2714880 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH53_RS13415 (LMH53_13415) 2708357..2710858 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
LMH53_RS13420 (LMH53_13420) 2710846..2711850 + 1005 WP_004199852.1 fimbrial protein -
LMH53_RS13425 (LMH53_13425) 2711983..2713275 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LMH53_RS13430 (LMH53_13430) 2713292..2714614 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
LMH53_RS13435 (LMH53_13435) 2714614..2714880 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LMH53_RS13440 (LMH53_13440) 2715146..2715472 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LMH53_RS13445 (LMH53_13445) 2715469..2715969 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LMH53_RS13450 (LMH53_13450) 2715947..2717326 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LMH53_RS13455 (LMH53_13455) 2717672..2718826 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LMH53_RS13460 (LMH53_13460) 2718807..2719730 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T225741 WP_004199851.1 NZ_CP087629:c2714614-2713292 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T225741 NZ_CP121297:3692720-3693649 [Salmonella enterica subsp. enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTTAGGCTATTAATGGCTGCGCTGCCGCATGTGGCAAAGGAGTCTTGCTT
CGCCCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTCCCTCGCCTGTCGGTAGATATCGATCTGGCGTATA
AGGCCTATGCGGATCGCGATACCGATCTGGCTACCATCAATGACGCCTTGATGCGTATTACTGAATCACTGAACGGCAGA
CCGGGGATCACCGCTATCCGGCAGGAGAACAAAGCGGATGAAAAGCGCATCATTGTTAACACCGCCGACGCGCAGATAAA
GATTGAAGTTAGCCCAGTCTGGCGTGGGCTGCTGTTGCCAGCAACAGAAATGCCGGTATGTGAACAGGTGGAAATGGAGT
ATGGCTTCACCACGATGAATGTCGTCTCGCAGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTACTGAATATGCTGGAGAAACCGGGCCTGACGCGCGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCGCCGAACTGGGATACATCGCGGATCGCAACTCTTTACGCAC
AGGAATTTTCAGGAATGACGCAGCGGGAAACATCGCTGGAGTCACTTTTATCAGTAACGACTTTGCTGCCACAAACGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCAGCTATAAGCAAATTACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCGGCTATTCGCTGGAAGCTGCGTAATCTGGCGGTACTGAAGGAAAAGAACCCGGCCAAGT
ATGCGGCGACGGTGAACAAGTTAGAAGGCGTTCTGGAGCAGTACTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT225741 WP_002904790.1 NZ_CP087629:c2714880-2714614 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT225741 NZ_CP121297:3691951-3692733 [Salmonella enterica subsp. enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAAAACACCCAACCCGGTCAGGTGTTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GCCGTGAGCCAGACTGGGTGGACGCGGTTTATTGCCTGCAAACGCAGTGGGAAAAACCGGTTCGCGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCCCACTATACCGAACCGGGTAAACCACAGGTCTGGCTCGCGCTTCCGGCTTATGTCAA
GCTGCCGGGATGGTTCGCCGCCTTTGAACAATCCGCGATGTTTGTCACGCTGTATACCTCTGGCCTCACCGTTGATGTAA
CACCATTTACGACAACACTGAATATCGGCGACCGACAGTTAACAGGCAGTGTCCCGGAACTGGCCGCTTATGAGATCGCC
GGCGGTGTTCCCTCGTTGATCTCATTCGAACATGCCGATGCGCTGTTTCAGGGGATGAACCTTCTCAGCCCGCGTAAATT
ACAGACACTGCTCTGCGCCAGCCATTCGGTTAAAACCAACCGGGTAATGCTCTATCTTGCCCGGCGCAATGAGCATCCTT
ATTTTCGGTATCTCGATCAAAGCGATATAGAAACAGGTACGGGAAAGCGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References