Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3883552..3884147 | Replicon | chromosome |
Accession | NC_010125 | ||
Organism | Gluconacetobacter diazotrophicus PAl 5 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | GDI_RS19410 | Protein ID | WP_012554491.1 |
Coordinates | 3883552..3883734 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | GDI_RS17960 | Protein ID | WP_012554492.1 |
Coordinates | 3883752..3884147 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GDI_RS17925 | 3879053..3879235 | - | 183 | WP_012554488.1 | hypothetical protein | - |
GDI_RS17930 | 3879518..3880198 | - | 681 | WP_012228581.1 | TetR/AcrR family transcriptional regulator | - |
GDI_RS17935 | 3880382..3881983 | + | 1602 | WP_144880527.1 | efflux transporter outer membrane subunit | - |
GDI_RS17940 | 3882159..3882572 | + | 414 | WP_012228583.1 | RNA polymerase-binding protein DksA | - |
GDI_RS17950 | 3882750..3883076 | - | 327 | WP_012228584.1 | hypothetical protein | - |
GDI_RS17955 | 3883070..3883450 | - | 381 | WP_043458994.1 | hypothetical protein | - |
GDI_RS19410 | 3883552..3883734 | + | 183 | WP_012554491.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
GDI_RS17960 | 3883752..3884147 | + | 396 | WP_012554492.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
GDI_RS17965 | 3884439..3885080 | - | 642 | Protein_3595 | IS481-like element ISGdi9 family transposase | - |
GDI_RS19415 | 3885183..3886240 | + | 1058 | WP_157864088.1 | IS630-like element ISGdi4 family transposase | - |
GDI_RS17980 | 3886402..3887926 | + | 1525 | Protein_3597 | IS21 family transposase | - |
GDI_RS17985 | 3887916..3888695 | + | 780 | WP_012222757.1 | IS21-like element ISGdi17 family helper ATPase IstB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6642.77 Da Isoelectric Point: 11.7334
>T22573 WP_012554491.1 NC_010125:3883552-3883734 [Gluconacetobacter diazotrophicus PA1 5]
MNSADLIRELKKAGWMEVRSRGSHHIFRHPDHGHSVTVPHPKKGLGKGLVAAIRKQAGLK
MNSADLIRELKKAGWMEVRSRGSHHIFRHPDHGHSVTVPHPKKGLGKGLVAAIRKQAGLK
Download Length: 183 bp
>T22573 NC_010125:3883552-3883734 [Gluconacetobacter diazotrophicus PA1 5]
ATGAACAGCGCCGACCTGATCCGGGAATTGAAGAAAGCGGGATGGATGGAGGTTCGGTCGCGTGGCTCTCACCACATATT
CCGCCACCCCGATCACGGACACTCGGTCACGGTGCCCCATCCCAAGAAGGGCTTGGGAAAGGGATTGGTCGCCGCCATTC
GCAAGCAGGCCGGATTGAAATGA
ATGAACAGCGCCGACCTGATCCGGGAATTGAAGAAAGCGGGATGGATGGAGGTTCGGTCGCGTGGCTCTCACCACATATT
CCGCCACCCCGATCACGGACACTCGGTCACGGTGCCCCATCCCAAGAAGGGCTTGGGAAAGGGATTGGTCGCCGCCATTC
GCAAGCAGGCCGGATTGAAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14142.76 Da Isoelectric Point: 4.1316
>AT22573 WP_012554492.1 NC_010125:3883752-3884147 [Gluconacetobacter diazotrophicus PA1 5]
MRYPIVIERGSDAEAYGVVVPDLPGCFSAGDTFDEAVSNASEAIALWVEDAIDNGQSIPRPSSLDGLRASLEWSGPEWIW
GFASVDPTLFDDTSERVNITLPRRVLARLDSRAKDAGETRSGFIAKLALSA
MRYPIVIERGSDAEAYGVVVPDLPGCFSAGDTFDEAVSNASEAIALWVEDAIDNGQSIPRPSSLDGLRASLEWSGPEWIW
GFASVDPTLFDDTSERVNITLPRRVLARLDSRAKDAGETRSGFIAKLALSA
Download Length: 396 bp
>AT22573 NC_010125:3883752-3884147 [Gluconacetobacter diazotrophicus PA1 5]
ATGCGATATCCTATCGTGATCGAGCGCGGTTCGGACGCTGAGGCATATGGCGTTGTCGTGCCTGATTTGCCGGGGTGCTT
CTCCGCCGGCGACACGTTCGACGAGGCGGTGAGCAATGCTTCCGAGGCCATCGCTCTATGGGTCGAAGATGCCATCGATA
ACGGGCAGTCCATCCCGCGTCCGTCGTCGCTCGATGGCCTGCGCGCCAGCCTGGAATGGTCTGGACCGGAATGGATCTGG
GGCTTTGCGAGCGTCGATCCTACGTTGTTCGACGATACGTCCGAGCGTGTGAACATCACACTTCCGCGTCGTGTCCTGGC
TCGGCTGGACAGCCGGGCAAAAGATGCGGGAGAAACACGCTCTGGGTTTATCGCCAAGCTGGCGCTAAGCGCATGA
ATGCGATATCCTATCGTGATCGAGCGCGGTTCGGACGCTGAGGCATATGGCGTTGTCGTGCCTGATTTGCCGGGGTGCTT
CTCCGCCGGCGACACGTTCGACGAGGCGGTGAGCAATGCTTCCGAGGCCATCGCTCTATGGGTCGAAGATGCCATCGATA
ACGGGCAGTCCATCCCGCGTCCGTCGTCGCTCGATGGCCTGCGCGCCAGCCTGGAATGGTCTGGACCGGAATGGATCTGG
GGCTTTGCGAGCGTCGATCCTACGTTGTTCGACGATACGTCCGAGCGTGTGAACATCACACTTCCGCGTCGTGTCCTGGC
TCGGCTGGACAGCCGGGCAAAAGATGCGGGAGAAACACGCTCTGGGTTTATCGCCAAGCTGGCGCTAAGCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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