Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3883552..3884147 Replicon chromosome
Accession NC_010125
Organism Gluconacetobacter diazotrophicus PAl 5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GDI_RS19410 Protein ID WP_012554491.1
Coordinates 3883552..3883734 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GDI_RS17960 Protein ID WP_012554492.1
Coordinates 3883752..3884147 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDI_RS17925 3879053..3879235 - 183 WP_012554488.1 hypothetical protein -
GDI_RS17930 3879518..3880198 - 681 WP_012228581.1 TetR/AcrR family transcriptional regulator -
GDI_RS17935 3880382..3881983 + 1602 WP_144880527.1 efflux transporter outer membrane subunit -
GDI_RS17940 3882159..3882572 + 414 WP_012228583.1 RNA polymerase-binding protein DksA -
GDI_RS17950 3882750..3883076 - 327 WP_012228584.1 hypothetical protein -
GDI_RS17955 3883070..3883450 - 381 WP_043458994.1 hypothetical protein -
GDI_RS19410 3883552..3883734 + 183 WP_012554491.1 type II toxin-antitoxin system HicA family toxin Toxin
GDI_RS17960 3883752..3884147 + 396 WP_012554492.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GDI_RS17965 3884439..3885080 - 642 Protein_3595 IS481-like element ISGdi9 family transposase -
GDI_RS19415 3885183..3886240 + 1058 WP_157864088.1 IS630-like element ISGdi4 family transposase -
GDI_RS17980 3886402..3887926 + 1525 Protein_3597 IS21 family transposase -
GDI_RS17985 3887916..3888695 + 780 WP_012222757.1 IS21-like element ISGdi17 family helper ATPase IstB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6642.77 Da        Isoelectric Point: 11.7334

>T22573 WP_012554491.1 NC_010125:3883552-3883734 [Gluconacetobacter diazotrophicus PA1 5]
MNSADLIRELKKAGWMEVRSRGSHHIFRHPDHGHSVTVPHPKKGLGKGLVAAIRKQAGLK

Download         Length: 183 bp

>T22573 NC_010125:3883552-3883734 [Gluconacetobacter diazotrophicus PA1 5]
ATGAACAGCGCCGACCTGATCCGGGAATTGAAGAAAGCGGGATGGATGGAGGTTCGGTCGCGTGGCTCTCACCACATATT
CCGCCACCCCGATCACGGACACTCGGTCACGGTGCCCCATCCCAAGAAGGGCTTGGGAAAGGGATTGGTCGCCGCCATTC
GCAAGCAGGCCGGATTGAAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14142.76 Da        Isoelectric Point: 4.1316

>AT22573 WP_012554492.1 NC_010125:3883752-3884147 [Gluconacetobacter diazotrophicus PA1 5]
MRYPIVIERGSDAEAYGVVVPDLPGCFSAGDTFDEAVSNASEAIALWVEDAIDNGQSIPRPSSLDGLRASLEWSGPEWIW
GFASVDPTLFDDTSERVNITLPRRVLARLDSRAKDAGETRSGFIAKLALSA

Download         Length: 396 bp

>AT22573 NC_010125:3883752-3884147 [Gluconacetobacter diazotrophicus PA1 5]
ATGCGATATCCTATCGTGATCGAGCGCGGTTCGGACGCTGAGGCATATGGCGTTGTCGTGCCTGATTTGCCGGGGTGCTT
CTCCGCCGGCGACACGTTCGACGAGGCGGTGAGCAATGCTTCCGAGGCCATCGCTCTATGGGTCGAAGATGCCATCGATA
ACGGGCAGTCCATCCCGCGTCCGTCGTCGCTCGATGGCCTGCGCGCCAGCCTGGAATGGTCTGGACCGGAATGGATCTGG
GGCTTTGCGAGCGTCGATCCTACGTTGTTCGACGATACGTCCGAGCGTGTGAACATCACACTTCCGCGTCGTGTCCTGGC
TCGGCTGGACAGCCGGGCAAAAGATGCGGGAGAAACACGCTCTGGGTTTATCGCCAAGCTGGCGCTAAGCGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References