Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4198029..4198648 Replicon chromosome
Accession NZ_CP087623
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02280

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LMH50_RS20915 Protein ID WP_002892050.1
Coordinates 4198430..4198648 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LMH50_RS20910 Protein ID WP_002892066.1
Coordinates 4198029..4198403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH50_RS20900 (LMH50_20900) 4193181..4194374 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LMH50_RS20905 (LMH50_20905) 4194397..4197543 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LMH50_RS20910 (LMH50_20910) 4198029..4198403 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LMH50_RS20915 (LMH50_20915) 4198430..4198648 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LMH50_RS20920 (LMH50_20920) 4198807..4199373 + 567 WP_002892030.1 maltose O-acetyltransferase -
LMH50_RS20925 (LMH50_20925) 4199345..4199485 - 141 WP_004147370.1 hypothetical protein -
LMH50_RS20930 (LMH50_20930) 4199506..4199976 + 471 WP_002892026.1 YlaC family protein -
LMH50_RS20935 (LMH50_20935) 4199951..4201402 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LMH50_RS20940 (LMH50_20940) 4201503..4202201 + 699 WP_002892021.1 GNAT family protein -
LMH50_RS20945 (LMH50_20945) 4202198..4202338 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LMH50_RS20950 (LMH50_20950) 4202338..4202601 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225715 WP_002892050.1 NZ_CP087623:4198430-4198648 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T225715 NZ_CP121295:1102915-1103328 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT225715 WP_002892066.1 NZ_CP087623:4198029-4198403 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT225715 NZ_CP121295:1102668-1102934 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References