Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2742648..2744236 Replicon chromosome
Accession NZ_CP087623
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02280

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag LMH50_RS13580 Protein ID WP_004199851.1
Coordinates 2742648..2743970 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LMH50_RS13585 Protein ID WP_002904790.1
Coordinates 2743970..2744236 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH50_RS13565 (LMH50_13565) 2737713..2740214 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
LMH50_RS13570 (LMH50_13570) 2740202..2741206 + 1005 WP_004199852.1 fimbrial protein -
LMH50_RS13575 (LMH50_13575) 2741339..2742631 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LMH50_RS13580 (LMH50_13580) 2742648..2743970 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
LMH50_RS13585 (LMH50_13585) 2743970..2744236 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LMH50_RS13590 (LMH50_13590) 2744502..2744828 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LMH50_RS13595 (LMH50_13595) 2744825..2745325 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LMH50_RS13600 (LMH50_13600) 2745303..2746682 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LMH50_RS13605 (LMH50_13605) 2747028..2748182 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LMH50_RS13610 (LMH50_13610) 2748163..2749086 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T225714 WP_004199851.1 NZ_CP087623:c2743970-2742648 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T225714 NZ_CP121295:c1032971-1032042 [Salmonella enterica subsp. enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTTAGGCTATTAATGGCTGCGCTGCCGCATGTGGCAAAGGAGTCTTGCTT
CGCCCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTCCCTCGCCTGTCGGTAGATATCGATCTGGCGTATA
AGGCCTATGCGGATCGCGATACCGATCTGGCTACCATCAATGACGCCTTGATGCGTATTACTGAATCACTGAACGGCAGA
CCGGGGATCACCGCTATCCGGCAGGAGAACAAAGCGGATGAAAAGCGCATCATTGTTAACACCGCCGACGCGCAGATAAA
GATTGAAGTTAGCCCAGTCTGGCGTGGGCTGCTGTTGCCAGCAACAGAAATGCCGGTATGTGAACAGGTGGAAATGGAGT
ATGGCTTCACCACGATGAATGTCGTCTCGCAGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTACTGAATATGCTGGAGAAACCGGGCCTGACGCGCGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCGCCGAACTGGGATACATCGCGGATCGCAACTCTTTACGCAC
AGGAATTTTCAGGAATGACGCAGCGGGAAACATCGCTGGAGTCACTTTTATCAGTAACGACTTTGCTGCCACAAACGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCAGCTATAAGCAAATTACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCGGCTATTCGCTGGAAGCTGCGTAATCTGGCGGTACTGAAGGAAAAGAACCCGGCCAAGT
ATGCGGCGACGGTGAACAAGTTAGAAGGCGTTCTGGAGCAGTACTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT225714 WP_002904790.1 NZ_CP087623:c2744236-2743970 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT225714 NZ_CP121295:c1033740-1032958 [Salmonella enterica subsp. enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAAAACACCCAACCCGGTCAGGTGTTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GCCGTGAGCCAGACTGGGTGGACGCGGTTTATTGCCTGCAAACGCAGTGGGAAAAACCGGTTCGCGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCCCACTATACCGAACCGGGTAAACCACAGGTCTGGCTCGCGCTTCCGGCTTATGTCAA
GCTGCCGGGATGGTTCGCCGCCTTTGAACAATCCGCGATGTTTGTCACGCTGTATACCTCTGGCCTCACCGTTGATGTAA
CACCATTTACGACAACACTGAATATCGGCGACCGACAGTTAACAGGCAGTGTCCCGGAACTGGCCGCTTATGAGATCGCC
GGCGGTGTTCCCTCGTTGATCTCATTCGAACATGCCGATGCGCTGTTTCAGGGGATGAACCTTCTCAGCCCGCGTAAATT
ACAGACACTGCTCTGCGCCAGCCATTCGGTTAAAACCAACCGGGTAATGCTCTATCTTGCCCGGCGCAATGAGCATCCTT
ATTTTCGGTATCTCGATCAAAGCGATATAGAAACAGGTACGGGAAAGCGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References