Detailed information of TA system TA022570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 1039474..1040005
• Replicon: chromosome
• Accession: NC_010125
• Organism: Gluconacetobacter diazotrophicus PAl 5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A9HCN8
• Locus tag: GDI_RS04880
• Protein ID: WP_012223901.1
• Coordinates: 1039474..1039764 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GDI_RS04885
• Protein ID: WP_041249296.1
• Coordinates: 1039757..1040005 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDI_RS04865	1034903..1035172	+	270	WP_012223894.1	HU family DNA-binding protein	-
GDI_RS19650	1035254..1036783	+	1530	WP_157870993.1	hypothetical protein	-
GDI_RS04870	1036903..1037328	-	426	WP_012223896.1	hypothetical protein	-
GDI_RS04875	1037334..1039316	-	1983	WP_012223897.1	conjugal transfer protein TraG	-
GDI_RS04880	1039474..1039764	-	291	WP_012223901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GDI_RS04885	1039757..1040005	-	249	WP_041249296.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GDI_RS04890	1040085..1040357	-	273	WP_012223909.1	type II toxin-antitoxin system ParD family antitoxin	-
GDI_RS04895	1040448..1042202	-	1755	WP_012223910.1	VirD2 family relaxase/mobilization nuclease	-
GDI_RS19655	1042186..1042398	-	213	WP_157870994.1	hypothetical protein	-
GDI_RS04900	1042913..1043452	+	540	Protein_972	IS481 family transposase	-
GDI_RS04905	1043506..1044354	-	849	Protein_973	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	972254..1042113	69859
	-	flank	IS/Tn	-	-	1042874..1043452	578

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (13-63)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11026.47 Da
• Isoelectric Point: 6.6416

>T22570 WP_012223901.1 NC_010125:c1039764-1039474 [Gluconacetobacter diazotrophicus PA1 5]
MPSYTLSGEADSDVQAIIALSIRNWGWARAERYILDLHTAFETLGTYPDMGADIGDLRTGYFRFVHDSHAVLYRKTGEGI
FIVRVLHQRQEPKHYL

Nucleotide

• Length: 291 bp

>T22570 NC_010125:c1039764-1039474 [Gluconacetobacter diazotrophicus PA1 5]
ATGCCTAGCTACACGCTTTCCGGCGAAGCGGATTCCGACGTTCAGGCCATTATCGCGCTTTCGATCCGGAATTGGGGATG
GGCGCGCGCCGAGCGCTATATCCTCGACCTGCATACGGCCTTCGAGACGCTGGGGACCTATCCCGACATGGGAGCGGATA
TCGGCGATCTGCGGACCGGATATTTTCGCTTCGTCCATGACAGCCACGCTGTACTCTATCGGAAGACGGGTGAAGGGATC
TTTATCGTTCGTGTCCTGCATCAGCGTCAGGAGCCGAAACACTATCTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9175.27 Da
• Isoelectric Point: 4.7223

>AT22570 WP_041249296.1 NC_010125:c1040005-1039757 [Gluconacetobacter diazotrophicus PA1 5]
MASMNVSVPDPMRDWVQRRIDSGQYASVSDYVRDLIRRDQTQAEERQALVEVLVQGEQSGVSKRTIPDILAAMKTAHDAT
DA

Nucleotide

• Length: 249 bp

>AT22570 NC_010125:c1040005-1039757 [Gluconacetobacter diazotrophicus PA1 5]
ATGGCTTCCATGAATGTATCCGTGCCGGATCCGATGCGTGATTGGGTTCAGCGCCGTATCGACAGTGGGCAATATGCAAG
CGTCAGCGATTACGTGCGCGACCTGATCCGGCGCGACCAGACACAGGCCGAGGAACGGCAGGCTCTGGTCGAGGTCCTGG
TTCAGGGCGAACAGAGCGGTGTGAGCAAACGCACGATTCCCGACATCCTCGCGGCGATGAAGACGGCCCACGACGCGACG
GATGCCTAG

Structures

Toxin

• AlphaFold DB: A9HCN8