Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4732509..4733025 Replicon chromosome
Accession NZ_CP087618
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02162

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LMH58_RS22780 Protein ID WP_004178374.1
Coordinates 4732509..4732793 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH58_RS22785 Protein ID WP_002886901.1
Coordinates 4732783..4733025 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH58_RS22755 (4727993) 4727993..4728256 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
LMH58_RS22760 (4728386) 4728386..4728559 + 174 WP_032408826.1 hypothetical protein -
LMH58_RS22765 (4728562) 4728562..4729305 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH58_RS22770 (4729662) 4729662..4731800 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LMH58_RS22775 (4732041) 4732041..4732505 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH58_RS22780 (4732509) 4732509..4732793 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH58_RS22785 (4732783) 4732783..4733025 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH58_RS22790 (4733103) 4733103..4735013 - 1911 WP_004178373.1 PRD domain-containing protein -
LMH58_RS22795 (4735036) 4735036..4736190 - 1155 WP_004178372.1 lactonase family protein -
LMH58_RS22800 (4736257) 4736257..4736997 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T225696 WP_004178374.1 NZ_CP087618:c4732793-4732509 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225696 NZ_CP121294:1270377-1270553 [Escherichia coli O155:H21]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225696 WP_002886901.1 NZ_CP087618:c4733025-4732783 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225696 NZ_CP121294:1270599-1271015 [Escherichia coli O155:H21]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTAAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References