Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3979334..3979953 Replicon chromosome
Accession NZ_CP087618
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02162

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LMH58_RS19240 Protein ID WP_002892050.1
Coordinates 3979735..3979953 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LMH58_RS19235 Protein ID WP_002892066.1
Coordinates 3979334..3979708 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH58_RS19225 (3974486) 3974486..3975679 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LMH58_RS19230 (3975702) 3975702..3978848 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LMH58_RS19235 (3979334) 3979334..3979708 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LMH58_RS19240 (3979735) 3979735..3979953 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LMH58_RS19245 (3980112) 3980112..3980678 + 567 WP_002892030.1 maltose O-acetyltransferase -
LMH58_RS19250 (3980650) 3980650..3980790 - 141 WP_004147370.1 hypothetical protein -
LMH58_RS19255 (3980811) 3980811..3981281 + 471 WP_002892026.1 YlaC family protein -
LMH58_RS19260 (3981256) 3981256..3982707 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LMH58_RS19265 (3982808) 3982808..3983506 + 699 WP_002892021.1 GNAT family protein -
LMH58_RS19270 (3983503) 3983503..3983643 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LMH58_RS19275 (3983643) 3983643..3983906 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225693 WP_002892050.1 NZ_CP087618:3979735-3979953 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T225693 NZ_CP121294:c1038858-1038751 [Escherichia coli O155:H21]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT225693 WP_002892066.1 NZ_CP087618:3979334-3979708 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT225693 NZ_CP121294:1038911-1038972 [Escherichia coli O155:H21]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References