225682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841828..842485 Replicon chromosome
Accession NZ_CP087618
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02162

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LMH58_RS04155 Protein ID WP_002916310.1
Coordinates 842075..842485 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH58_RS04150 Protein ID WP_002916312.1
Coordinates 841828..842094 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH58_RS04125 (837403) 837403..838434 + 1032 WP_004176137.1 IS630-like element ISEc33 family transposase -
LMH58_RS04130 (838536) 838536..839264 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH58_RS04135 (839314) 839314..839625 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LMH58_RS04140 (839789) 839789..840448 + 660 WP_002916317.1 hemolysin III family protein -
LMH58_RS04145 (840599) 840599..841582 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
LMH58_RS04150 (841828) 841828..842094 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH58_RS04155 (842075) 842075..842485 + 411 WP_002916310.1 protein YgfX Toxin
LMH58_RS04160 (842492) 842492..843013 - 522 WP_004144730.1 flavodoxin FldB -
LMH58_RS04165 (843114) 843114..844010 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH58_RS04170 (844033) 844033..844746 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH58_RS04175 (844752) 844752..846485 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 837403..838434 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T225682 WP_002916310.1 NZ_CP087618:842075-842485 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T225682 NZ_CP121269:c4590069-4589698 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225682 WP_002916312.1 NZ_CP087618:841828-842094 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225682 NZ_CP121269:c4590314-4590072 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References