225681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 694036..694715 Replicon chromosome
Accession NZ_CP087618
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02162

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag LMH58_RS03405 Protein ID WP_020324801.1
Coordinates 694374..694715 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag LMH58_RS03400 Protein ID WP_020324792.1
Coordinates 694036..694353 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH58_RS03375 (689250) 689250..692402 + 3153 WP_022631414.1 AIDA repeat-containing protein -
LMH58_RS03380 (692495) 692495..692734 + 240 WP_020324820.1 DUF905 domain-containing protein -
LMH58_RS03385 (692837) 692837..693295 + 459 WP_020324813.1 antirestriction protein -
LMH58_RS03390 (693311) 693311..693787 + 477 WP_020324797.1 RadC family protein -
LMH58_RS03395 (693796) 693796..694023 + 228 WP_020324796.1 DUF987 domain-containing protein -
LMH58_RS03400 (694036) 694036..694353 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LMH58_RS03405 (694374) 694374..694715 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
LMH58_RS03410 (694831) 694831..695664 + 834 WP_020324805.1 DUF4942 domain-containing protein -
LMH58_RS03420 (695967) 695967..696473 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
LMH58_RS03425 (696573) 696573..698414 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T225681 WP_020324801.1 NZ_CP087618:694374-694715 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T225681 NZ_CP121269:c4461700-4461515 [Enterobacter hormaechei subsp. xiangfangensis]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT225681 WP_020324792.1 NZ_CP087618:694036-694353 [Klebsiella pneumoniae subsp. pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT225681 NZ_CP121269:c4461500-4461096 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTAATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References