Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 19167..19702 Replicon plasmid pDD02172-3
Accession NZ_CP087614
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02172

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LMH59_RS27850 Protein ID WP_016531292.1
Coordinates 19167..19454 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837JUA1
Locus tag LMH59_RS27855 Protein ID WP_023317799.1
Coordinates 19451..19702 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH59_RS27830 (LMH59_27830) 14724..15479 + 756 WP_001568031.1 replication initiation protein RepE -
LMH59_RS27835 (LMH59_27835) 16296..16826 + 531 WP_023317796.1 hypothetical protein -
LMH59_RS27840 (LMH59_27840) 17080..17367 - 288 WP_016529486.1 hypothetical protein -
LMH59_RS27845 (LMH59_27845) 17457..18119 - 663 WP_023317797.1 division plane positioning ATPase MipZ -
LMH59_RS27850 (LMH59_27850) 19167..19454 - 288 WP_016531292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH59_RS27855 (LMH59_27855) 19451..19702 - 252 WP_023317799.1 hypothetical protein Antitoxin
LMH59_RS27860 (LMH59_27860) 19798..21066 - 1269 WP_023317800.1 Y-family DNA polymerase -
LMH59_RS27865 (LMH59_27865) 21066..21497 - 432 WP_023317801.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LMH59_RS27870 (LMH59_27870) 21903..23390 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
LMH59_RS27875 (LMH59_27875) 23639..24610 + 972 WP_004152353.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81442 81442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.16 Da        Isoelectric Point: 10.4373

>T225678 WP_016531292.1 NZ_CP087614:c19454-19167 [Klebsiella pneumoniae subsp. pneumoniae]
MTYTVKFREDALKEWNKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDNQLIIAIVAVGK
RERSDVYTLASERMK

Download         Length: 288 bp

>T225678 NZ_CP121269:c2709267-2709164 [Enterobacter hormaechei subsp. xiangfangensis]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9239.60 Da        Isoelectric Point: 4.2108

>AT225678 WP_023317799.1 NZ_CP087614:c19702-19451 [Klebsiella pneumoniae subsp. pneumoniae]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELIKLVAERSNQPLFDVDLD
KYL

Download         Length: 252 bp

>AT225678 NZ_CP121269:2709151-2709360 [Enterobacter hormaechei subsp. xiangfangensis]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837JUA1

References