Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 116372..117042 | Replicon | plasmid pDD02172-1 |
| Accession | NZ_CP087612 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02172 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LMH59_RS26190 | Protein ID | WP_004213072.1 |
| Coordinates | 116372..116815 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LMH59_RS26195 | Protein ID | WP_004213073.1 |
| Coordinates | 116812..117042 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH59_RS26155 (LMH59_26155) | 111783..112058 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LMH59_RS26160 (LMH59_26160) | 112121..112612 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LMH59_RS26165 (LMH59_26165) | 112661..113581 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LMH59_RS26170 (LMH59_26170) | 113672..114075 | + | 404 | Protein_127 | GAF domain-containing protein | - |
| LMH59_RS26175 (LMH59_26175) | 114593..115228 | - | 636 | WP_165475474.1 | mucoid phenotype regulator RmpA2 | - |
| LMH59_RS26180 (LMH59_26180) | 115645..115949 | + | 305 | Protein_129 | transposase | - |
| LMH59_RS26185 (LMH59_26185) | 115972..116223 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| LMH59_RS26190 (LMH59_26190) | 116372..116815 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LMH59_RS26195 (LMH59_26195) | 116812..117042 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LMH59_RS26200 (LMH59_26200) | 117650..118783 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LMH59_RS26205 (LMH59_26205) | 118799..119092 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LMH59_RS26210 (LMH59_26210) | 119082..119288 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LMH59_RS26215 (LMH59_26215) | 119640..119930 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| LMH59_RS26220 (LMH59_26220) | 119920..120819 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaDHA-1 / qnrB4 / blaSHV-187 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..281138 | 281138 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T225673 WP_004213072.1 NZ_CP087612:c116815-116372 [Klebsiella pneumoniae subsp. pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T225673 NZ_CP121269:623531-623818 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCCTATAGAGTATGAGTGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGCGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA
ATGCCTATAGAGTATGAGTGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGCGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT225673 WP_004213073.1 NZ_CP087612:c117042-116812 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT225673 NZ_CP121269:623805-624107 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|