Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4683214..4684049 | Replicon | chromosome |
| Accession | NZ_CP087611 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02172 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | LMH59_RS22560 | Protein ID | WP_001559913.1 |
| Coordinates | 4683214..4683591 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | LMH59_RS22565 | Protein ID | WP_032408847.1 |
| Coordinates | 4683681..4684049 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH59_RS22520 (4678479) | 4678479..4678745 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| LMH59_RS22525 (4678745) | 4678745..4679417 | + | 673 | Protein_4418 | DUF4400 domain-containing protein | - |
| LMH59_RS22530 (4679428) | 4679428..4680144 | + | 717 | WP_232152072.1 | RES domain-containing protein | - |
| LMH59_RS22535 (4680512) | 4680512..4680700 | - | 189 | Protein_4420 | transposase | - |
| LMH59_RS22540 (4680717) | 4680717..4681828 | - | 1112 | Protein_4421 | IS3 family transposase | - |
| LMH59_RS22545 (4682278) | 4682278..4682427 | - | 150 | Protein_4422 | restriction endonuclease subunit M | - |
| LMH59_RS22550 (4682512) | 4682512..4682709 | - | 198 | WP_032408848.1 | DUF957 domain-containing protein | - |
| LMH59_RS22555 (4682729) | 4682729..4683217 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| LMH59_RS22560 (4683214) | 4683214..4683591 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| LMH59_RS22565 (4683681) | 4683681..4684049 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LMH59_RS22570 (4684226) | 4684226..4684447 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| LMH59_RS22575 (4684516) | 4684516..4684992 | - | 477 | WP_032408846.1 | RadC family protein | - |
| LMH59_RS22580 (4685007) | 4685007..4685492 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| LMH59_RS22585 (4685584) | 4685584..4686402 | - | 819 | WP_001559911.1 | DUF932 domain-containing protein | - |
| LMH59_RS22590 (4686502) | 4686502..4686735 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| LMH59_RS22595 (4686814) | 4686814..4687269 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4671591..4702005 | 30414 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T225667 WP_001559913.1 NZ_CP087611:c4683591-4683214 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T225667 NZ_CP121262:c4687398-4687087 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT225667 WP_032408847.1 NZ_CP087611:c4684049-4683681 [Klebsiella pneumoniae subsp. pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT225667 NZ_CP121262:c4687086-4686796 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |