Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 710615..711294 Replicon chromosome
Accession NZ_CP087611
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02172

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag LMH59_RS03515 Protein ID WP_020324801.1
Coordinates 710953..711294 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag LMH59_RS03510 Protein ID WP_020324792.1
Coordinates 710615..710932 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH59_RS03485 (705829) 705829..708981 + 3153 WP_022631414.1 AIDA repeat-containing protein -
LMH59_RS03490 (709074) 709074..709313 + 240 WP_020324820.1 DUF905 domain-containing protein -
LMH59_RS03495 (709416) 709416..709874 + 459 WP_020324813.1 antirestriction protein -
LMH59_RS03500 (709890) 709890..710366 + 477 WP_020324797.1 RadC family protein -
LMH59_RS03505 (710375) 710375..710602 + 228 WP_020324796.1 DUF987 domain-containing protein -
LMH59_RS03510 (710615) 710615..710932 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LMH59_RS03515 (710953) 710953..711294 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
LMH59_RS03520 (711410) 711410..712243 + 834 WP_020324805.1 DUF4942 domain-containing protein -
LMH59_RS03530 (712546) 712546..713052 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
LMH59_RS03535 (713152) 713152..714993 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 664268..712243 47975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T225653 WP_020324801.1 NZ_CP087611:710953-711294 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T225653 NZ_CP121261:c5835133-5834951 [Achromobacter spanius]
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAACCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGAATCGGACTGGTTACGAAGCTGC
TGACGCAAGCCGGCCTGAAGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT225653 WP_020324792.1 NZ_CP087611:710615-710932 [Klebsiella pneumoniae subsp. pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT225653 NZ_CP121261:c5834901-5834509 [Achromobacter spanius]
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCAGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAACTGTGGATTGAAACCGCGTTGG
ATAGTGGCACCCCCGTGCCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCAGAATTCGCAGGCTGGATTTGGGCC
ATCGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCGTTGACGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References