Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
Location | 710615..711294 | Replicon | chromosome |
Accession | NZ_CP087611 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02172 |
Toxin (Protein)
Gene name | ykfI | Uniprot ID | A0A0C7K7A4 |
Locus tag | LMH59_RS03515 | Protein ID | WP_020324801.1 |
Coordinates | 710953..711294 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | yfjZ | Uniprot ID | A0A0C7KEL2 |
Locus tag | LMH59_RS03510 | Protein ID | WP_020324792.1 |
Coordinates | 710615..710932 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LMH59_RS03485 (705829) | 705829..708981 | + | 3153 | WP_022631414.1 | AIDA repeat-containing protein | - |
LMH59_RS03490 (709074) | 709074..709313 | + | 240 | WP_020324820.1 | DUF905 domain-containing protein | - |
LMH59_RS03495 (709416) | 709416..709874 | + | 459 | WP_020324813.1 | antirestriction protein | - |
LMH59_RS03500 (709890) | 709890..710366 | + | 477 | WP_020324797.1 | RadC family protein | - |
LMH59_RS03505 (710375) | 710375..710602 | + | 228 | WP_020324796.1 | DUF987 domain-containing protein | - |
LMH59_RS03510 (710615) | 710615..710932 | + | 318 | WP_020324792.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
LMH59_RS03515 (710953) | 710953..711294 | + | 342 | WP_020324801.1 | TA system toxin CbtA family protein | Toxin |
LMH59_RS03520 (711410) | 711410..712243 | + | 834 | WP_020324805.1 | DUF4942 domain-containing protein | - |
LMH59_RS03530 (712546) | 712546..713052 | + | 507 | WP_002917636.1 | G/U mismatch-specific DNA glycosylase | - |
LMH59_RS03535 (713152) | 713152..714993 | - | 1842 | WP_004174339.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | fimA / fimI / fimC / fimD / fimD / fimF / fimG | 664268..712243 | 47975 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12818.91 Da Isoelectric Point: 9.1484
>T225653 WP_020324801.1 NZ_CP087611:710953-711294 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR
Download Length: 342 bp
>T225653 NZ_CP121261:c5835133-5834951 [Achromobacter spanius]
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAACCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGAATCGGACTGGTTACGAAGCTGC
TGACGCAAGCCGGCCTGAAGTAG
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAACCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGAATCGGACTGGTTACGAAGCTGC
TGACGCAAGCCGGCCTGAAGTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11915.51 Da Isoelectric Point: 6.6246
>AT225653 WP_020324792.1 NZ_CP087611:710615-710932 [Klebsiella pneumoniae subsp. pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR
Download Length: 318 bp
>AT225653 NZ_CP121261:c5834901-5834509 [Achromobacter spanius]
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCAGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAACTGTGGATTGAAACCGCGTTGG
ATAGTGGCACCCCCGTGCCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCAGAATTCGCAGGCTGGATTTGGGCC
ATCGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCGTTGACGCACTAG
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCAGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAACTGTGGATTGAAACCGCGTTGG
ATAGTGGCACCCCCGTGCCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCAGAATTCGCAGGCTGGATTTGGGCC
ATCGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCGTTGACGCACTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C7K7A4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C7KEL2 |