Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 154828..155471 | Replicon | plasmid pDD01304-2 |
| Accession | NZ_CP087608 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01304 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | D8L2J9 |
| Locus tag | LMH54_RS29275 | Protein ID | WP_001044770.1 |
| Coordinates | 155055..155471 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | LMH54_RS29270 | Protein ID | WP_001261282.1 |
| Coordinates | 154828..155058 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH54_RS29235 (150051) | 150051..150830 | - | 780 | WP_013214009.1 | site-specific integrase | - |
| LMH54_RS29240 (151014) | 151014..152018 | - | 1005 | WP_011977814.1 | hypothetical protein | - |
| LMH54_RS29245 (152048) | 152048..152251 | - | 204 | WP_011977813.1 | hypothetical protein | - |
| LMH54_RS29250 (152297) | 152297..152818 | - | 522 | WP_013214008.1 | hypothetical protein | - |
| LMH54_RS29255 (152876) | 152876..153268 | - | 393 | WP_011977811.1 | hypothetical protein | - |
| LMH54_RS29260 (153305) | 153305..154249 | - | 945 | WP_011977810.1 | hypothetical protein | - |
| LMH54_RS29265 (154410) | 154410..154871 | - | 462 | WP_014343465.1 | hypothetical protein | - |
| LMH54_RS29270 (154828) | 154828..155058 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LMH54_RS29275 (155055) | 155055..155471 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LMH54_RS29280 (155545) | 155545..157107 | + | 1563 | WP_004206609.1 | AAA family ATPase | - |
| LMH54_RS29285 (157092) | 157092..158114 | + | 1023 | WP_000361404.1 | helicase UvrD | - |
| LMH54_RS29290 (158370) | 158370..159067 | + | 698 | WP_223174630.1 | IS1 family transposase | - |
| LMH54_RS29295 (159096) | 159096..159368 | + | 273 | Protein_210 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaKPC-2 / catA2 | - | 1..169136 | 169136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T225649 WP_001044770.1 NZ_CP087608:155055-155471 [Klebsiella pneumoniae subsp. pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
>T225649 NZ_CP121261:1597241-1597660 [Achromobacter spanius]
ATGATTCTGCTGGACACCAATGTCATCTCCGAGCCGCTGCGCCAGGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCCTGGAAACCTTGTTTCTTTCCGCCGTCACCGTCGCTGAATTGCGCTTTGGCGTGGCCTGCATGCCAGTGGGAA
AACGGCGCGACGCCTTGCATGGCGACCTGGAACAGCGCGTCCTGGCCCTGTTTGCCGGGCGCATCCTGGCTTTCGATACG
TCCGCCAGCCTGGAATACGTCGCGCTGATGGCGCGTGCGCGGGCCTCGGGCCAGGCCATCGGCGGGCCAGACGGCTACAT
CGCCGCCACCGCCGCCGCGCACGGGATGAGCGTCGCGACCCGGGACGTGGCGCCCTTTGAAGCCGCCGGCGTGTCCGTCA
TCAACCCGTGGGGCGCCTAG
ATGATTCTGCTGGACACCAATGTCATCTCCGAGCCGCTGCGCCAGGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCCTGGAAACCTTGTTTCTTTCCGCCGTCACCGTCGCTGAATTGCGCTTTGGCGTGGCCTGCATGCCAGTGGGAA
AACGGCGCGACGCCTTGCATGGCGACCTGGAACAGCGCGTCCTGGCCCTGTTTGCCGGGCGCATCCTGGCTTTCGATACG
TCCGCCAGCCTGGAATACGTCGCGCTGATGGCGCGTGCGCGGGCCTCGGGCCAGGCCATCGGCGGGCCAGACGGCTACAT
CGCCGCCACCGCCGCCGCGCACGGGATGAGCGTCGCGACCCGGGACGTGGCGCCCTTTGAAGCCGCCGGCGTGTCCGTCA
TCAACCCGTGGGGCGCCTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT225649 WP_001261282.1 NZ_CP087608:154828-155058 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT225649 NZ_CP121261:1596993-1597244 [Achromobacter spanius]
ATGCCTATGTTGACCGTGAGAAATATCTCTGAAGAGGTACATCGCGCCCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGTTCGCTGCTTCTGC
AGATCGGCCGCCAGGCCAGGCTCACCGACGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA
ATGCCTATGTTGACCGTGAGAAATATCTCTGAAGAGGTACATCGCGCCCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGTTCGCTGCTTCTGC
AGATCGGCCGCCAGGCCAGGCTCACCGACGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GYM2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZG3 |