Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5047175..5048856 | Replicon | chromosome |
| Accession | NZ_CP087606 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01304 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | LMH54_RS24915 | Protein ID | WP_002885155.1 |
| Coordinates | 5047175..5048092 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | LMH54_RS24920 | Protein ID | WP_004151732.1 |
| Coordinates | 5048098..5048856 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH54_RS24895 (LMH54_24895) | 5042481..5044001 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| LMH54_RS24900 (LMH54_24900) | 5043998..5044996 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| LMH54_RS24905 (LMH54_24905) | 5045027..5045968 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| LMH54_RS24910 (LMH54_24910) | 5046043..5047050 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| LMH54_RS24915 (LMH54_24915) | 5047175..5048092 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LMH54_RS24920 (LMH54_24920) | 5048098..5048856 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LMH54_RS24925 (LMH54_24925) | 5048942..5049670 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| LMH54_RS24930 (LMH54_24930) | 5049943..5052090 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| LMH54_RS24935 (LMH54_24935) | 5052320..5053006 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T225643 WP_002885155.1 NZ_CP087606:c5048092-5047175 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T225643 NZ_CP121246:c2066586-2066296 [Agrobacterium pusense]
ATGAGTGAAAAGTTCACGAACTTCAATCCTGCCGAACACCTCAAGAGCGATGAAGCAATTGAAGTATTTTTGGAGGACGC
GTTCGCAACCAACGACGCGGCATACATAGCAAATGCGCTTGGTGTTATCGCGCGCGCAAAGGGTATGACGCGGGTGGCTC
GGGAAACCGGACTTGCCAGAGAGCATCTCTACAAATCCCTCAGCGAGGCAGGAAATCCGACGTTAGAAACCACAATAGCC
GTTCTCAACGCCCTGGGCTTGCAACTCACCAGCAAACACAAGGCAGCATGA
ATGAGTGAAAAGTTCACGAACTTCAATCCTGCCGAACACCTCAAGAGCGATGAAGCAATTGAAGTATTTTTGGAGGACGC
GTTCGCAACCAACGACGCGGCATACATAGCAAATGCGCTTGGTGTTATCGCGCGCGCAAAGGGTATGACGCGGGTGGCTC
GGGAAACCGGACTTGCCAGAGAGCATCTCTACAAATCCCTCAGCGAGGCAGGAAATCCGACGTTAGAAACCACAATAGCC
GTTCTCAACGCCCTGGGCTTGCAACTCACCAGCAAACACAAGGCAGCATGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT225643 WP_004151732.1 NZ_CP087606:c5048856-5048098 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT225643 NZ_CP121246:c2066881-2066579 [Agrobacterium pusense]
ATGCAGATCAAGCAATCTACTACGTTCAAAAAATGGTTTGGGAAGCTGAAGGATGAACGCGGCAAAGCTATTATTGCGTC
CCGCTTGAACAGGCTTTCCTTTGGTCACGCAGGTGACGTTGCGCCGGTTGGCAATGGAATCAGCGAATTGCGCATCCACT
ACGGGCCGGGCTATCGGGTCTATTTCATCATTTCGGATGATGTCGTTGTCGTTCTCCTTTGTGGCGGTAACAAGAGCACG
CAGGAGAAGGACATAAGAGCCGCAAGGGTGATTGCGGCGCAATGGAGTGATGACGATGAGTGA
ATGCAGATCAAGCAATCTACTACGTTCAAAAAATGGTTTGGGAAGCTGAAGGATGAACGCGGCAAAGCTATTATTGCGTC
CCGCTTGAACAGGCTTTCCTTTGGTCACGCAGGTGACGTTGCGCCGGTTGGCAATGGAATCAGCGAATTGCGCATCCACT
ACGGGCCGGGCTATCGGGTCTATTTCATCATTTCGGATGATGTCGTTGTCGTTCTCCTTTGTGGCGGTAACAAGAGCACG
CAGGAGAAGGACATAAGAGCCGCAAGGGTGATTGCGGCGCAATGGAGTGATGACGATGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |