Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4890991..4891507 Replicon chromosome
Accession NZ_CP087606
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01304

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LMH54_RS24115 Protein ID WP_002886902.1
Coordinates 4890991..4891275 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH54_RS24120 Protein ID WP_002886901.1
Coordinates 4891265..4891507 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH54_RS24090 (LMH54_24090) 4886475..4886738 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LMH54_RS24095 (LMH54_24095) 4886868..4887041 + 174 WP_002886906.1 hypothetical protein -
LMH54_RS24100 (LMH54_24100) 4887044..4887787 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH54_RS24105 (LMH54_24105) 4888144..4890282 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LMH54_RS24110 (LMH54_24110) 4890523..4890987 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH54_RS24115 (LMH54_24115) 4890991..4891275 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH54_RS24120 (LMH54_24120) 4891265..4891507 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH54_RS24125 (LMH54_24125) 4891585..4893495 - 1911 WP_004152270.1 PRD domain-containing protein -
LMH54_RS24130 (LMH54_24130) 4893518..4894672 - 1155 WP_002886900.1 lactonase family protein -
LMH54_RS24135 (LMH54_24135) 4894738..4895478 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T225642 WP_002886902.1 NZ_CP087606:c4891275-4890991 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225642 NZ_CP121245:2050565-2050855 [Agrobacterium pusense]
ATGGGATTTCGCCTTTCTCTGCCTGCGGAAGAAGACGTCATCCGCATAGCGCAAGAAGGCATCGACCTATTTGGACCTCA
GCAAGCGCGAAAGTACCATCGCGAACTTTTCGCAATATTCGACTTGATATCACGGAATCCGAGGATCGCACGCGAGCGTA
ACGAGTTGTCGCCGTCGGTGCGCATTCATCCGTTCAGAGCACATCTGGTGGTCTATCGCGTTGAGGCGGACGACGACGTC
CTCATCGTCCGCGTCCGCCATGGGCACGAGGACTGGGGCAATGAGCCTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225642 WP_002886901.1 NZ_CP087606:c4891507-4891265 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225642 NZ_CP121245:2050311-2050562 [Agrobacterium pusense]
ATGGTGACCATGAATATTTCGCTGCCCGGCCAGATGAAGGAATGGGTCGAAGCGCAGTCTAAAACGGGCCGTTACTCCAA
TGCCAGCGACTATGTCCGAGATCTCATCCGAAAGGATCAGGAGCGGAGCGAAAAGATCGCTGCCATGCAGGGTCTGGTGG
ACGAAGGATTGCAGGCTCCCTCCGGTCATCGTTGTGAAGATGCCTTGTTTGCTGAGGCCGAAGCCCGCTCCATGAAACGT
AAAATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References