Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2081488..2082108 Replicon chromosome
Accession NC_010086
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag BMUL_RS24975 Protein ID WP_012217495.1
Coordinates 2081488..2081805 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag BMUL_RS24980 Protein ID WP_006398012.1
Coordinates 2081809..2082108 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMUL_RS24965 2078023..2079456 - 1434 WP_012217494.1 aldehyde dehydrogenase family protein -
BMUL_RS24970 2079485..2081125 - 1641 WP_006398015.1 acetolactate synthase large subunit -
BMUL_RS24975 2081488..2081805 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMUL_RS24980 2081809..2082108 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
BMUL_RS24985 2082148..2083434 - 1287 WP_012217496.1 DUF445 domain-containing protein -
BMUL_RS24990 2083548..2084768 - 1221 WP_012217497.1 FAD-dependent oxidoreductase -
BMUL_RS24995 2084758..2085084 - 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
BMUL_RS25000 2085102..2085590 - 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
BMUL_RS25005 2085605..2086873 - 1269 WP_012467811.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T22564 WP_012217495.1 NC_010086:2081488-2081805 [Burkholderia multivorans ATCC 17616]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T22564 NC_010086:2081488-2081805 [Burkholderia multivorans ATCC 17616]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT22564 WP_006398012.1 NC_010086:2081809-2082108 [Burkholderia multivorans ATCC 17616]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT22564 NC_010086:2081809-2082108 [Burkholderia multivorans ATCC 17616]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
CTGCCTGCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References