225639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2270785..2272373 Replicon chromosome
Accession NZ_CP087606
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01304

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag LMH54_RS11195 Protein ID WP_004199851.1
Coordinates 2271051..2272373 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LMH54_RS11190 Protein ID WP_002904790.1
Coordinates 2270785..2271051 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH54_RS11165 (LMH54_11165) 2265935..2266858 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
LMH54_RS11170 (LMH54_11170) 2266839..2267993 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LMH54_RS11175 (LMH54_11175) 2268339..2269718 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LMH54_RS11180 (LMH54_11180) 2269696..2270196 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LMH54_RS11185 (LMH54_11185) 2270193..2270519 + 327 WP_002904788.1 hydroxyisourate hydrolase -
LMH54_RS11190 (LMH54_11190) 2270785..2271051 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LMH54_RS11195 (LMH54_11195) 2271051..2272373 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
LMH54_RS11200 (LMH54_11200) 2272390..2273682 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LMH54_RS11205 (LMH54_11205) 2273815..2274819 - 1005 WP_004199852.1 fimbrial protein -
LMH54_RS11210 (LMH54_11210) 2274807..2277308 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T225639 WP_004199851.1 NZ_CP087606:2271051-2272373 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T225639 NZ_CP121233:c2655278-2655135 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT225639 WP_002904790.1 NZ_CP087606:2270785-2271051 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT225639 NZ_CP121233:2655015-2655202 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References