225630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878385..879039 Replicon chromosome
Accession NZ_CP087606
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01304

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH54_RS04435 Protein ID WP_004144731.1
Coordinates 878632..879039 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH54_RS04430 Protein ID WP_002916312.1
Coordinates 878385..878651 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH54_RS04405 (LMH54_04405) 873541..874974 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH54_RS04410 (LMH54_04410) 875093..875821 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH54_RS04415 (LMH54_04415) 875871..876182 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH54_RS04420 (LMH54_04420) 876346..877005 + 660 WP_002916317.1 hemolysin III family protein -
LMH54_RS04425 (LMH54_04425) 877156..878139 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH54_RS04430 (LMH54_04430) 878385..878651 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH54_RS04435 (LMH54_04435) 878632..879039 + 408 WP_004144731.1 protein YgfX Toxin
LMH54_RS04440 (LMH54_04440) 879046..879567 - 522 WP_002916308.1 flavodoxin FldB -
LMH54_RS04445 (LMH54_04445) 879668..880564 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH54_RS04450 (LMH54_04450) 880587..881300 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH54_RS04455 (LMH54_04455) 881306..883039 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225630 WP_004144731.1 NZ_CP087606:878632-879039 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225630 NZ_CP121223:4000972-4001259 [Shigella flexneri 2a]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225630 WP_002916312.1 NZ_CP087606:878385-878651 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225630 NZ_CP121223:4000733-4000972 [Shigella flexneri 2a]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References