22563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1265894..1266428 Replicon chromosome
Accession NC_010086
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name parE Uniprot ID J4RBB5
Locus tag BMUL_RS21435 Protein ID WP_006413674.1
Coordinates 1265894..1266193 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag BMUL_RS21440 Protein ID WP_006413656.1
Coordinates 1266183..1266428 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMUL_RS21420 1262243..1263550 + 1308 WP_012216990.1 shikimate transporter -
BMUL_RS21425 1263585..1264313 - 729 WP_012216991.1 HNH endonuclease -
BMUL_RS21430 1264484..1265785 + 1302 WP_006403538.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
BMUL_RS21435 1265894..1266193 - 300 WP_006413674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMUL_RS21440 1266183..1266428 - 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BMUL_RS21445 1266567..1267337 + 771 WP_006403543.1 helix-turn-helix domain-containing protein -
BMUL_RS21450 1267374..1269674 - 2301 WP_012467925.1 ATP-dependent DNA helicase -
BMUL_RS21455 1269671..1271374 - 1704 WP_012216994.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.08 Da        Isoelectric Point: 8.4461

>T22563 WP_006413674.1 NC_010086:c1266193-1265894 [Burkholderia multivorans ATCC 17616]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T22563 NC_010086:c1266193-1265894 [Burkholderia multivorans ATCC 17616]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT22563 WP_006413656.1 NC_010086:c1266428-1266183 [Burkholderia multivorans ATCC 17616]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT22563 NC_010086:c1266428-1266183 [Burkholderia multivorans ATCC 17616]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTACGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KLL7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References