Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2153911..2154469 Replicon chromosome
Accession NZ_CP087598
Organism Paracoccus sp. MA

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag LOS78_RS17785 Protein ID WP_104491150.1
Coordinates 2154167..2154469 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOS78_RS17780 Protein ID WP_230377653.1
Coordinates 2153911..2154177 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOS78_RS17735 (LOS78_17735) 2149065..2149856 - 792 WP_072463921.1 quinoprotein dehydrogenase-associated SoxYZ-like carrier -
LOS78_RS17740 (LOS78_17740) 2149861..2150547 - 687 WP_028714065.1 cytochrome c-550 PedF -
LOS78_RS17745 (LOS78_17745) 2150723..2151238 + 516 WP_051416320.1 hypothetical protein -
LOS78_RS17750 (LOS78_17750) 2151260..2151703 - 444 Protein_2104 aldehyde dehydrogenase family protein -
LOS78_RS17755 (LOS78_17755) 2151906..2152340 + 435 WP_230377651.1 hypothetical protein -
LOS78_RS17760 (LOS78_17760) 2152337..2152822 + 486 WP_230377652.1 hypothetical protein -
LOS78_RS17765 (LOS78_17765) 2152826..2153059 + 234 WP_104491154.1 hypothetical protein -
LOS78_RS17770 (LOS78_17770) 2153062..2153391 + 330 WP_104491153.1 hypothetical protein -
LOS78_RS17775 (LOS78_17775) 2153614..2153910 + 297 WP_104491152.1 hypothetical protein -
LOS78_RS17780 (LOS78_17780) 2153911..2154177 + 267 WP_230377653.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LOS78_RS17785 (LOS78_17785) 2154167..2154469 + 303 WP_104491150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOS78_RS17790 (LOS78_17790) 2154931..2155125 + 195 WP_010400642.1 hypothetical protein -
LOS78_RS17795 (LOS78_17795) 2155106..2155300 - 195 WP_230377654.1 hypothetical protein -
LOS78_RS17800 (LOS78_17800) 2155311..2155736 - 426 WP_230377655.1 type II toxin-antitoxin system VapC family toxin -
LOS78_RS17805 (LOS78_17805) 2155736..2155981 - 246 WP_230377656.1 type II toxin-antitoxin system VapB family antitoxin -
LOS78_RS17810 (LOS78_17810) 2156127..2156279 - 153 WP_230377657.1 hypothetical protein -
LOS78_RS17815 (LOS78_17815) 2156437..2157369 - 933 WP_230375481.1 IS5 family transposase -
LOS78_RS17825 (LOS78_17825) 2158034..2158987 - 954 WP_230377658.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2156437..2157369 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(16-77)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11641.46 Da        Isoelectric Point: 10.5908

>T225626 WP_104491150.1 NZ_CP087598:2154167-2154469 [Paracoccus sp. MA]
MTFELKFLPSALKEWKKLGATLREQFRKKLAERLEQPRVPADALHGLEDHYKIKLRSAGYRLVYRVEDAEITVTVVAVGR
RERSEVYKAASARRDDRPKS

Download         Length: 303 bp

>T225626 NZ_CP121223:c2807433-2807215 [Shigella flexneri 2a]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9759.30 Da        Isoelectric Point: 4.2537

>AT225626 WP_230377653.1 NZ_CP087598:2153911-2154177 [Paracoccus sp. MA]
MTLWRLNMQRVEAQIAVSVSDLKKSPTAIMDQAQGEAVAVLNHNRVMAYMVPADVYEAMMERLDDLALVDVIKARADETP
ISVGLDDL

Download         Length: 267 bp

>AT225626 NZ_CP121223:c2807833-2807459 [Shigella flexneri 2a]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References