Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1665268..1665797 Replicon chromosome
Accession NZ_CP087598
Organism Paracoccus sp. MA

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LOS78_RS15315 Protein ID WP_152366699.1
Coordinates 1665268..1665555 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LOS78_RS15320 Protein ID WP_230377387.1
Coordinates 1665552..1665797 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOS78_RS15295 (LOS78_15295) 1661034..1661762 - 729 WP_024843951.1 IS21-like element ISPkr1 family helper ATPase IstB -
LOS78_RS15300 (LOS78_15300) 1661692..1663260 - 1569 WP_028717560.1 IS21 family transposase -
LOS78_RS15305 (LOS78_15305) 1663493..1664665 + 1173 WP_230377385.1 ATP-binding protein -
LOS78_RS15310 (LOS78_15310) 1664886..1665179 - 294 WP_230377386.1 hypothetical protein -
LOS78_RS15315 (LOS78_15315) 1665268..1665555 - 288 WP_152366699.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOS78_RS15320 (LOS78_15320) 1665552..1665797 - 246 WP_230377387.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LOS78_RS15325 (LOS78_15325) 1665902..1667263 - 1362 WP_230377388.1 plasmid recombination protein -
LOS78_RS15330 (LOS78_15330) 1667256..1668353 - 1098 WP_230377389.1 helix-turn-helix domain-containing protein -
LOS78_RS15340 (LOS78_15340) 1668821..1669840 + 1020 WP_230377390.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1655302..1668353 13051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10638.11 Da        Isoelectric Point: 6.4738

>T225625 WP_152366699.1 NZ_CP087598:c1665555-1665268 [Paracoccus sp. MA]
MKALAFTVAATVDLEAIWDYTEGEWGLAQARRYVQELRDTCHALASGQGRGRPVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDVERHL

Download         Length: 288 bp

>T225625 NZ_CP121223:c2770494-2770033 [Shigella flexneri 2a]
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8750.83 Da        Isoelectric Point: 7.2038

>AT225625 WP_230377387.1 NZ_CP087598:c1665797-1665552 [Paracoccus sp. MA]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEESGRAEGFDLDRFIARKMAGRN
A

Download         Length: 246 bp

>AT225625 NZ_CP121223:c2770877-2770566 [Shigella flexneri 2a]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References