Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1459733..1460403 Replicon chromosome
Accession NZ_CP087598
Organism Paracoccus sp. MA

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P8JDY4
Locus tag LOS78_RS14330 Protein ID WP_011748362.1
Coordinates 1459969..1460403 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5P8JE31
Locus tag LOS78_RS14325 Protein ID WP_018000085.1
Coordinates 1459733..1459972 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOS78_RS14300 (LOS78_14300) 1455762..1456106 - 345 WP_018000081.1 HNH endonuclease signature motif containing protein -
LOS78_RS14305 (LOS78_14305) 1456246..1456623 - 378 WP_230377234.1 DUF6362 family protein -
LOS78_RS14310 (LOS78_14310) 1456616..1456840 - 225 WP_230377236.1 hypothetical protein -
LOS78_RS14315 (LOS78_14315) 1457187..1459412 - 2226 WP_230377238.1 AAA family ATPase -
LOS78_RS14320 (LOS78_14320) 1459409..1459609 - 201 WP_230377239.1 hypothetical protein -
LOS78_RS14325 (LOS78_14325) 1459733..1459972 + 240 WP_018000085.1 Arc family DNA-binding protein Antitoxin
LOS78_RS14330 (LOS78_14330) 1459969..1460403 + 435 WP_011748362.1 type II toxin-antitoxin system VapC family toxin Toxin
LOS78_RS14335 (LOS78_14335) 1460391..1461107 - 717 WP_062563252.1 sigma-70 family RNA polymerase sigma factor -
LOS78_RS14340 (LOS78_14340) 1461205..1461438 - 234 WP_230377240.1 hypothetical protein -
LOS78_RS14345 (LOS78_14345) 1461532..1463691 - 2160 WP_230377242.1 hypothetical protein -
LOS78_RS14350 (LOS78_14350) 1464023..1464478 + 456 WP_230377243.1 DUF2924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1437288..1467979 30691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(3-42)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15536.75 Da        Isoelectric Point: 4.5849

>T225624 WP_011748362.1 NZ_CP087598:1459969-1460403 [Paracoccus sp. MA]
MIILDTNVVSETMKPAPEPRVIDWLNRQELTTLHLTTISLAELRFGIACLDAGRRRDDLDARLEQMLAEVFPARILSFDE
AAASAFGVLMATARRQGQAVSFADGAIAAIAAAQGYPVASRDTAPFAAMGVEVVDPWHEAAQGR

Download         Length: 435 bp

>T225624 NZ_CP121223:2688110-2688508 [Shigella flexneri 2a]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.79 Da        Isoelectric Point: 5.7012

>AT225624 WP_018000085.1 NZ_CP087598:1459733-1459972 [Paracoccus sp. MA]
MAQIVVRQIPEEVHRALKAQAAAHGRSAEAELREIIARAVLPQSRPRAGDLMRSIWSGAETDDLSVERDRTPAEPAGFE

Download         Length: 240 bp

>AT225624 NZ_CP121223:2687814-2688107 [Shigella flexneri 2a]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P8JDY4

Antitoxin

Source ID Structure
AlphaFold DB A0A5P8JE31

References