Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 960554..962301 Replicon chromosome
Accession NC_010086
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name doc Uniprot ID A0A0H3KM73
Locus tag BMUL_RS20200 Protein ID WP_012216806.1
Coordinates 960554..961450 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID J5C5E7
Locus tag BMUL_RS20205 Protein ID WP_006413828.1
Coordinates 961447..962301 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMUL_RS20170 955954..957033 - 1080 WP_006413812.1 porin -
BMUL_RS20175 957469..957786 + 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
BMUL_RS20180 957788..958099 + 312 WP_012216804.1 hypothetical protein -
BMUL_RS20185 958147..959217 + 1071 WP_006413805.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BMUL_RS20190 959210..959980 + 771 WP_012216805.1 SDR family oxidoreductase -
BMUL_RS20195 960008..960535 + 528 WP_006396778.1 cupin domain-containing protein -
BMUL_RS20200 960554..961450 + 897 WP_012216806.1 alpha/beta fold hydrolase Toxin
BMUL_RS20205 961447..962301 + 855 WP_006413828.1 IclR family transcriptional regulator Antitoxin
BMUL_RS20210 962298..963095 + 798 WP_012216807.1 SDR family oxidoreductase -
BMUL_RS20215 963088..964755 + 1668 WP_012216808.1 thiamine pyrophosphate-binding protein -
BMUL_RS20220 964748..965578 + 831 WP_012216809.1 aspartate dehydrogenase -
BMUL_RS20225 965656..967146 + 1491 WP_012216810.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30611.89 Da        Isoelectric Point: 8.0534

>T22562 WP_012216806.1 NC_010086:960554-961450 [Burkholderia multivorans ATCC 17616]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAVAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDLERRAA

Download         Length: 897 bp

>T22562 NC_010086:960554-961450 [Burkholderia multivorans ATCC 17616]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCATGCCGGCGCCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCATCGCCGTCGGCCGTCGATTACGCGGCGTCGCTCGACGC
GTGGCTCGATGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGAATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGCGCGCCGGCGGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAAGACGCGCGCGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCCGCCGATCTCGCCGGGTTTCGCGGCCGCACGGCGGTGGCCGTCGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGCGAGCGCATCGCGGCGGTCGCCGGCGTCGGACTGCAGGTGATTCCGCA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCGGACGTCTATTCGGCCTTGATCGACACGTTCTGCCGGCAGTGCGACCTCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.74 Da        Isoelectric Point: 6.9856

>AT22562 WP_006413828.1 NC_010086:961447-962301 [Burkholderia multivorans ATCC 17616]
MSEPLQSAAEPAKTEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDALRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT22562 NC_010086:961447-962301 [Burkholderia multivorans ATCC 17616]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAGCCCGCGAAGACCGAAGCGAGCTACGTCGTGCCGGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCTCTGGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACGGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTCTCGCTGGACGCGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGACGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGGATTTCGGTCGTCACCGCGCCGGTACGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGACGGGCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAGCACACGTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KM73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KMB1

References