225614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2217499..2218013 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LO764_RS11295 Protein ID WP_000581792.1
Coordinates 2217499..2217708 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LO764_RS11300 Protein ID WP_000138932.1
Coordinates 2217720..2218013 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS11275 (2213007) 2213007..2214365 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LO764_RS11280 (2214380) 2214380..2215450 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LO764_RS11285 (2215768) 2215768..2216970 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LO764_RS11290 (2217234) 2217234..2217371 - 138 WP_000828354.1 Lmo0850 family protein -
LO764_RS11295 (2217499) 2217499..2217708 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LO764_RS11300 (2217720) 2217720..2218013 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LO764_RS11305 (2218179) 2218179..2219663 + 1485 WP_000571549.1 cardiolipin synthase -
LO764_RS11310 (2219691) 2219691..2220338 + 648 WP_001187629.1 HD domain-containing protein -
LO764_RS11315 (2221151) 2221151..2222023 - 873 WP_000725802.1 membrane protein insertase YidC -
LO764_RS11320 (2222109) 2222109..2222750 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T225614 WP_000581792.1 NZ_CP087593:c2217708-2217499 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T225614 NZ_CP121222:106386-106871 [Shigella flexneri 2a]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCAGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGAGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT225614 WP_000138932.1 NZ_CP087593:c2218013-2217720 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT225614 NZ_CP121222:106114-106398 [Shigella flexneri 2a]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References