22561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 778322..779013 Replicon chromosome
Accession NC_010086
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3KND5
Locus tag BMUL_RS19245 Protein ID WP_012216645.1
Coordinates 778558..779013 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag BMUL_RS19240 Protein ID WP_012216644.1
Coordinates 778322..778561 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMUL_RS19220 773689..773928 - 240 WP_006416205.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BMUL_RS19225 774332..775015 - 684 WP_012216641.1 Fe2+-dependent dioxygenase -
BMUL_RS19230 775012..775767 - 756 WP_012216642.1 sel1 repeat family protein -
BMUL_RS19235 775771..778017 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
BMUL_RS19240 778322..778561 + 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
BMUL_RS19245 778558..779013 + 456 WP_012216645.1 type II toxin-antitoxin system VapC family toxin Toxin
BMUL_RS19250 779111..780406 - 1296 WP_012216646.1 aspartate carbamoyltransferase -
BMUL_RS19255 780639..780773 + 135 WP_006396654.1 entericidin A/B family lipoprotein -
BMUL_RS19260 780867..781442 - 576 WP_012216647.1 hypothetical protein -
BMUL_RS19265 781707..782657 - 951 WP_080512386.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.65 Da        Isoelectric Point: 9.8210

>T22561 WP_012216645.1 NC_010086:778558-779013 [Burkholderia multivorans ATCC 17616]
MILVDTNVISEPLRRKPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGTAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T22561 NC_010086:778558-779013 [Burkholderia multivorans ATCC 17616]
ATGATCCTTGTTGATACGAACGTCATTTCCGAACCGCTGCGGCGCAAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGCTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGCGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGAGCAAGGCCTATGCACGCATTCGCGCGCACGCCCGTGCCGGCGGCACCGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGACCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT22561 WP_012216644.1 NC_010086:778322-778561 [Burkholderia multivorans ATCC 17616]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT22561 NC_010086:778322-778561 [Burkholderia multivorans ATCC 17616]
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KND5

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References