225607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1952657..1953433 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LO764_RS09605 Protein ID WP_000031108.1
Coordinates 1952657..1952809 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LO764_RS09610 Protein ID WP_001251224.1
Coordinates 1952834..1953433 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS09590 (1948620) 1948620..1949441 + 822 WP_000669376.1 RluA family pseudouridine synthase -
LO764_RS09595 (1949904) 1949904..1951289 - 1386 WP_000116224.1 class II fumarate hydratase -
LO764_RS09600 (1951485) 1951485..1951880 - 396 WP_000901021.1 hypothetical protein -
LO764_RS09605 (1952657) 1952657..1952809 - 153 WP_000031108.1 SAS053 family protein Toxin
LO764_RS09610 (1952834) 1952834..1953433 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LO764_RS09615 (1953592) 1953592..1954062 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LO764_RS09620 (1954067) 1954067..1955194 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
LO764_RS09625 (1955345) 1955345..1956067 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LO764_RS09630 (1956060) 1956060..1957517 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T225607 WP_000031108.1 NZ_CP087593:c1952809-1952657 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T225607 NZ_CP121204:c2622224-2622117 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT225607 WP_001251224.1 NZ_CP087593:c1953433-1952834 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT225607 NZ_CP121204:2622040-2622100 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References