Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 865123..865600 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag LO764_RS04265 Protein ID WP_000052077.1
Coordinates 865123..865311 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LO764_RS04270 Protein ID WP_001059690.1
Coordinates 865340..865600 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS04235 (861164) 861164..861634 + 471 WP_000824472.1 hypothetical protein -
LO764_RS04240 (861975) 861975..862661 + 687 WP_001548082.1 thermonuclease family protein -
LO764_RS04245 (863018) 863018..863218 + 201 WP_001059082.1 cold-shock protein -
LO764_RS04250 (863714) 863714..863932 - 219 WP_000005886.1 hypothetical protein -
LO764_RS04255 (863994) 863994..864278 - 285 WP_001004395.1 hypothetical protein -
LO764_RS04260 (864366) 864366..864935 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
LO764_RS04265 (865123) 865123..865311 - 189 WP_000052077.1 hypothetical protein Toxin
LO764_RS04270 (865340) 865340..865600 - 261 WP_001059690.1 hypothetical protein Antitoxin
LO764_RS04275 (865941) 865941..866144 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LO764_RS04280 (866141) 866141..866377 - 237 WP_000368687.1 hypothetical protein -
LO764_RS04285 (866602) 866602..867183 + 582 WP_001140693.1 histidine phosphatase family protein -
LO764_RS04290 (867256) 867256..867873 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
LO764_RS04295 (868028) 868028..868522 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
LO764_RS04300 (868921) 868921..869343 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
LO764_RS04305 (869491) 869491..870207 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T225604 WP_000052077.1 NZ_CP087593:c865311-865123 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T225604 NZ_CP121204:2158946-2159134 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT225604 WP_001059690.1 NZ_CP087593:c865600-865340 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT225604 NZ_CP121204:2158657-2158917 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References