Detailed information of TA system TA225601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 696853..698399
• Replicon: chromosome
• Accession: NZ_CP087590
• Organism: Vibrio sp. VB16

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IUZ65_RS03420
• Protein ID: WP_195702403.1
• Coordinates: 696853..698154 (-)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IUZ65_RS03425
• Protein ID: WP_195702404.1
• Coordinates: 698154..698399 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUZ65_RS03400 (IUZ65_003400)	693025..693924	-	900	WP_195702399.1	methyl-accepting chemotaxis protein	-
IUZ65_RS03405 (IUZ65_003405)	693921..694214	-	294	WP_195702400.1	nitrate/nitrite transporter NrtS	-
IUZ65_RS03410 (IUZ65_003410)	694329..695207	+	879	WP_195702401.1	AraC family transcriptional regulator	-
IUZ65_RS03415 (IUZ65_003415)	695428..696759	+	1332	WP_195702402.1	hypothetical protein	-
IUZ65_RS03420 (IUZ65_003420)	696853..698154	-	1302	WP_195702403.1	type II toxin-antitoxin system HipA family toxin	Toxin
IUZ65_RS03425 (IUZ65_003425)	698154..698399	-	246	WP_195702404.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IUZ65_RS03430 (IUZ65_003430)	699071..700138	+	1068	WP_195702405.1	hypothetical protein	-
IUZ65_RS03435 (IUZ65_003435)	700217..700528	-	312	WP_195702406.1	hypothetical protein	-
IUZ65_RS03440 (IUZ65_003440)	700613..701161	-	549	WP_195702407.1	recombinase family protein	-
IUZ65_RS03445 (IUZ65_003445)	701653..702612	+	960	WP_195702408.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48690.50 Da
• Isoelectric Point: 9.1652

>T225601 WP_195702403.1 NZ_CP087590:c698154-696853 [Vibrio sp. VB16]
MQKLIAYMNGELVGALEKRKNGAHTFQYDKSWVNNVKTRPLSLSLKLQLPPITSDAVINYFDNLLPDSPQVRDRIVSRYK
TSSKQPFDLLKEVGKDSVGAITLLPPELPYKKEPLNYEVLDDKKLEAVLSGYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LFVDGQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFIVPNVSIIETDSLKALAVERFDRRW
TKDKSGLIRLPQEDICQVFGMPSSIKYESQGGPSIAQIMALLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
KGGSYSLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEVNKILPRHFLDTAKAVNFNQDKMQKIMDEMKDALP
KAILQVKANLPKDFPEHISDSIFENAKKIIKKI

Nucleotide

• Length: 1302 bp

>T225601 NZ_CP121204:c2001362-2001210 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAAATGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGAGAGTCAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9250.67 Da
• Isoelectric Point: 6.2564

>AT225601 WP_195702404.1 NZ_CP087590:c698399-698154 [Vibrio sp. VB16]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLIQAMDLTLSIQEKTLVASLDENDES
W

Nucleotide

• Length: 246 bp

>AT225601 NZ_CP121204:c2001986-2001387 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA