Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 689619..691450 Replicon chromosome
Accession NZ_CP087590
Organism Vibrio sp. VB16

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IUZ65_RS03390 Protein ID WP_195702397.1
Coordinates 690086..691450 (-) Length 455 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IUZ65_RS03385 Protein ID WP_229637971.1
Coordinates 689619..690089 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUZ65_RS03350 (IUZ65_003350) 685033..685281 - 249 WP_195702389.1 DUF3297 family protein -
IUZ65_RS03355 (IUZ65_003355) 685703..686647 + 945 WP_195702390.1 sensor domain-containing diguanylate cyclase -
IUZ65_RS23405 686804..686938 + 135 WP_269213769.1 hypothetical protein -
IUZ65_RS03360 (IUZ65_003360) 686958..687461 - 504 WP_195702391.1 YgjV family protein -
IUZ65_RS03365 (IUZ65_003365) 687494..687919 - 426 WP_195702392.1 GFA family protein -
IUZ65_RS03370 (IUZ65_003370) 687983..688351 - 369 WP_195702393.1 VOC family protein -
IUZ65_RS03375 (IUZ65_003375) 688490..688999 - 510 WP_195702394.1 ATP-binding protein -
IUZ65_RS03380 (IUZ65_003380) 689026..689304 + 279 WP_195702395.1 LysR family transcriptional regulator -
IUZ65_RS03385 (IUZ65_003385) 689619..690089 - 471 WP_229637971.1 helix-turn-helix transcriptional regulator Antitoxin
IUZ65_RS03390 (IUZ65_003390) 690086..691450 - 1365 WP_195702397.1 HipA domain-containing protein Toxin
IUZ65_RS03395 (IUZ65_003395) 691804..692763 + 960 WP_195702398.1 transposase -
IUZ65_RS03400 (IUZ65_003400) 693025..693924 - 900 WP_195702399.1 methyl-accepting chemotaxis protein -
IUZ65_RS03405 (IUZ65_003405) 693921..694214 - 294 WP_195702400.1 nitrate/nitrite transporter NrtS -
IUZ65_RS03410 (IUZ65_003410) 694329..695207 + 879 WP_195702401.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-139)


Sequences

Toxin        


Download         Length: 455 a.a.        Molecular weight: 51810.61 Da        Isoelectric Point: 4.8673

>T225600 WP_195702397.1 NZ_CP087590:c691450-690086 [Vibrio sp. VB16]
MEELILQAFTKEQWLDVATISFPNSSKHNFRITELNYLGNYALEHHDKDDLHAVSINHPVSFFFDDIGKPGWLTFLDDIM
PSGASRRYWVKHLDIEDLTYDEQDYILLRFGTMSPVGNLRVKDSLPERHEVSDTLYFSVGDVINRAGDFLDYAQQRGAIA
GGATGAGGEAPKLLLRCSVEKDASDNKIWIDPYQDDNTNQDLHYLVKYPRGSRTTIDCNILRAEFYFYHELTEMGFETIS
IENMRLEEGINYPSLWLPRFDIKFNNQQHIERFGMESVYSILGKGAGVTLDHEATIRALIEKITQSHMVRRQGYDFDIQD
FVIEWVKRDLLNILFGNSDNHGRNTSFLKGDGFIKLAPIYDFAPMKADPEGIPRTTKWRAPLEVGGTYDFIGIADLLSDL
VASEILLEELRSTAKQCIDLKKRLADKGVPEQILEMPATGLNHISDKVTKWGLL

Download         Length: 1365 bp

>T225600 NZ_CP121204:c1167507-1167043 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTGGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17309.82 Da        Isoelectric Point: 10.7649

>AT225600 WP_229637971.1 NZ_CP087590:c690089-689619 [Vibrio sp. VB16]
MITNKTVSKESIKGTIDRLRASREKASTTRSTTTEAIEKTDQSVQTTQRVSKNTTSVSTADRKKAANHIIKRLLFSELTE
GQALKELRINVLGLKQDVYAKLVNVSRKTLSDIENDRGNYKTDILNKVFKPFGLKVGLLPSSPSMLNALLRGSDTE

Download         Length: 471 bp

>AT225600 NZ_CP121204:c1167849-1167520 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References