Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 608667..609970 | Replicon | chromosome |
| Accession | NC_010086 | ||
| Organism | Burkholderia multivorans ATCC 17616 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A0H3KN79 |
| Locus tag | BMUL_RS18575 | Protein ID | WP_012216544.1 |
| Coordinates | 608667..609278 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | BMUL_RS18580 | Protein ID | WP_012216545.1 |
| Coordinates | 609413..609970 (-) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BMUL_RS18555 | 603988..604779 | + | 792 | WP_012216541.1 | enoyl-CoA hydratase | - |
| BMUL_RS18560 | 604776..605915 | + | 1140 | WP_012216542.1 | enoyl-CoA hydratase/isomerase family protein | - |
| BMUL_RS18565 | 605968..606888 | - | 921 | WP_006412501.1 | LysR family transcriptional regulator | - |
| BMUL_RS18570 | 607067..608605 | + | 1539 | WP_012216543.1 | MFS transporter | - |
| BMUL_RS18575 | 608667..609278 | - | 612 | WP_012216544.1 | HD domain-containing protein | Toxin |
| BMUL_RS18580 | 609413..609970 | - | 558 | WP_012216545.1 | helix-turn-helix domain-containing protein | Antitoxin |
| BMUL_RS18585 | 610482..611885 | + | 1404 | WP_012216546.1 | membrane protein | - |
| BMUL_RS18590 | 612224..612955 | + | 732 | WP_012216547.1 | ribonuclease T2 | - |
| BMUL_RS18595 | 613131..613769 | - | 639 | WP_012468022.1 | cysteine hydrolase | - |
| BMUL_RS18600 | 613898..614914 | - | 1017 | WP_006412465.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22619.43 Da Isoelectric Point: 6.0800
>T22560 WP_012216544.1 NC_010086:c609278-608667 [Burkholderia multivorans ATCC 17616]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQARTSSQTQTHTHRP
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQARTSSQTQTHTHRP
Download Length: 612 bp
>T22560 NC_010086:c609278-608667 [Burkholderia multivorans ATCC 17616]
ATGAACCCCGACACGATCCGCGCACGACTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGACGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACATGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAGCTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCTGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACGAACGTCATCGCAAACACAAACGCACACGCACCGCCCATAA
ATGAACCCCGACACGATCCGCGCACGACTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGACGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACATGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAGCTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCTGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACGAACGTCATCGCAAACACAAACGCACACGCACCGCCCATAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20462.51 Da Isoelectric Point: 8.9550
>AT22560 WP_012216545.1 NC_010086:c609970-609413 [Burkholderia multivorans ATCC 17616]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFRVAQSTLSRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAA
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFRVAQSTLSRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAA
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
Download Length: 558 bp
>AT22560 NC_010086:c609970-609413 [Burkholderia multivorans ATCC 17616]
ATGCCCGATTCGCCGCTTCACACGCCGCCGCTGGGCCCGCAGCTAAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCCGCGTCGCGCAATCGACGCTCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCGGAACGCCTGCTCGCCGCGCGCCTCGACTCTGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGCG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTCCCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACGCTCGGCTGGCACGATTGCGCAGGACCGCCGAGCGTGGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTGTAG
ATGCCCGATTCGCCGCTTCACACGCCGCCGCTGGGCCCGCAGCTAAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCCGCGTCGCGCAATCGACGCTCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCGGAACGCCTGCTCGCCGCGCGCCTCGACTCTGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGCG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTCCCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACGCTCGGCTGGCACGATTGCGCAGGACCGCCGAGCGTGGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|