Detailed information of TA system TA225599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 228804..229372
• Replicon: chromosome
• Accession: NZ_CP087590
• Organism: Vibrio sp. VB16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IUZ65_RS01070
• Protein ID: WP_195704935.1
• Coordinates: 229088..229372 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IUZ65_RS01065
• Protein ID: WP_195704934.1
• Coordinates: 228804..229085 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUZ65_RS01050 (IUZ65_001050)	225021..226937	+	1917	WP_195704931.1	nucleoside-diphosphate sugar epimerase/dehydratase	-
IUZ65_RS01055 (IUZ65_001055)	226981..228147	+	1167	WP_195704932.1	nucleotide sugar dehydrogenase	-
IUZ65_RS01060 (IUZ65_001060)	228313..228669	+	357	Protein_200	MBL fold metallo-hydrolase	-
IUZ65_RS01065 (IUZ65_001065)	228804..229085	+	282	WP_195704934.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IUZ65_RS01070 (IUZ65_001070)	229088..229372	+	285	WP_195704935.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUZ65_RS01075 (IUZ65_001075)	229566..230201	+	636	WP_195704936.1	TetR/AcrR family transcriptional regulator	-
IUZ65_RS01080 (IUZ65_001080)	230210..231169	+	960	WP_195704937.1	DHH family phosphoesterase	-
IUZ65_RS01085 (IUZ65_001085)	231231..232235	+	1005	WP_195704938.1	NAD-dependent epimerase	-
IUZ65_RS01090 (IUZ65_001090)	232630..233997	-	1368	WP_195705161.1	phosphomannomutase CpsG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11345.18 Da
• Isoelectric Point: 6.0861

>T225599 WP_195704935.1 NZ_CP087590:229088-229372 [Vibrio sp. VB16]
MKLKWEHQSLDDRYDIFEYLYEFNALAAEKTDATIVNRAMLLLEHLLMGIEREDRRGRYLIIPEISMLLSYEFDGDLIRI
HRVIHTKKMFPEKS

Nucleotide

• Length: 285 bp

>T225599 NZ_CP121204:936091-936393 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATGGCAAGATACGTTGTATTGATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
CCCGATACCAGTAGATGAAGAAAGTATTTCATCGATCATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCAGAAAGTAAATATAGAAAAGCAACAGGA
CAAGCACCTATCAAAGAAGTGATGACACCTACAAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10963.16 Da
• Isoelectric Point: 5.7711

>AT225599 WP_195704934.1 NZ_CP087590:228804-229085 [Vibrio sp. VB16]
METRVQFRIDEQTKSLAQKAIERKGGTLSDACRKLAEDLAQEQRQFENHDSWLTDQINTAFDKYDQGEAKFFSHDEAERI
MEDRKNKIRNKAI

Nucleotide

• Length: 282 bp

>AT225599 NZ_CP121204:c936011-935945 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT