Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 925724..927249 Replicon chromosome
Accession NZ_CP087587
Organism Croceicoccus sp. Ery5

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag LOZ74_RS04410 Protein ID WP_230293064.1
Coordinates 925978..927249 (+) Length 424 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag LOZ74_RS04405 Protein ID WP_230293815.1
Coordinates 925724..925981 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ74_RS04385 921023..921307 - 285 WP_230293060.1 DUF4212 domain-containing protein -
LOZ74_RS04390 921462..922154 - 693 WP_230293061.1 exonuclease domain-containing protein -
LOZ74_RS04395 922151..924058 - 1908 WP_230293062.1 putative nucleotidyltransferase substrate binding domain-containing protein -
LOZ74_RS04400 924169..925389 + 1221 WP_230293063.1 amino acid permease -
LOZ74_RS04405 925724..925981 + 258 WP_230293815.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
LOZ74_RS04410 925978..927249 + 1272 WP_230293064.1 type II toxin-antitoxin system HipA family toxin Toxin
LOZ74_RS04415 927389..929236 + 1848 WP_230293065.1 DUF262 domain-containing protein -
LOZ74_RS04420 929246..932113 + 2868 WP_047822153.1 class I SAM-dependent DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-62)


Sequences

Toxin        


Download         Length: 424 a.a.        Molecular weight: 45470.06 Da        Isoelectric Point: 5.2441

>T225598 WP_230293064.1 NZ_CP087587:925978-927249 [Croceicoccus sp. Ery5]
VTLPILDTLMVWWDKRKAGELWIDKGGAMHFAYTPEWLADETAPALSHAMPKKQESFKDHACKAVFGGLLPEESQRTAIA
RALGVSPDNPFRLLEALGGDVAGALAFLPKHEEPLQDCSETTPEPLQEGELAKLLDRLPAVPMLAGEGGARLSLAGAQSK
LPVLVTADGGIAIPRLGEPSTHLIKPEPDRFAGLAANEAFCLALARAAGIDAATAEWREVAGKPLLLVERYDRMSVEGKT
KRLHQEDFAQALSVPSNRKYAAEGGPTFRDSFALLRSAATRPAREVLKLADAAIFNLIIGNADAHAKNYSLLRRENGEVV
LAPLYDLVATHMWKELSPKLAMRFGNAATLEEFDSKCVARFADEAGLGAPYIRRRVSDLADAVTEEIEKGVQVPGNPPED
AVAPIAEALSTRASAAALKLLEA

Download         Length: 1272 bp

>T225598 NZ_CP121204:879849-880166 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9151.75 Da        Isoelectric Point: 6.3200

>AT225598 WP_230293815.1 NZ_CP087587:925724-925981 [Croceicoccus sp. Ery5]
MLNVATIGQIIRDERKELGLRQDELAAASGVGLRFLVELERGKVTVQMGKVLDVLAALGCELQIKRPDGIVIAGRAVAPK
KDEAE

Download         Length: 258 bp

>AT225598 NZ_CP121204:879637-879846 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References