Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4440953..4441969 Replicon chromosome
Accession NZ_CP087584
Organism Providencia rettgeri strain L1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LMY39_RS20310 Protein ID WP_230233285.1
Coordinates 4440953..4441666 (-) Length 238 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LMY39_RS20315 Protein ID WP_210847063.1
Coordinates 4441706..4441969 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMY39_RS20300 (LMY39_20300) 4436902..4439949 - 3048 WP_282551101.1 formate dehydrogenase-N subunit alpha -
LMY39_RS20305 (LMY39_20305) 4440126..4440956 + 831 WP_042846771.1 formate dehydrogenase accessory sulfurtransferase FdhD -
LMY39_RS20310 (LMY39_20310) 4440953..4441666 - 714 WP_230233285.1 HipA domain-containing protein Toxin
LMY39_RS20315 (LMY39_20315) 4441706..4441969 - 264 WP_210847063.1 helix-turn-helix domain-containing protein Antitoxin
LMY39_RS20320 (LMY39_20320) 4442125..4442889 - 765 WP_042846773.1 hypothetical protein -
LMY39_RS20325 (LMY39_20325) 4443020..4444384 - 1365 WP_042846829.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LMY39_RS20330 (LMY39_20330) 4444512..4446161 - 1650 WP_042846774.1 membrane protein insertase YidC -
LMY39_RS20335 (LMY39_20335) 4446164..4446424 - 261 WP_042846775.1 membrane protein insertion efficiency factor YidD -
LMY39_RS20340 (LMY39_20340) 4446388..4446747 - 360 WP_072035181.1 ribonuclease P protein component -
LMY39_RS20345 (LMY39_20345) 4446769..4446912 - 144 WP_042846776.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(4-200)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 238 a.a.        Molecular weight: 27145.21 Da        Isoelectric Point: 7.4722

>T225597 WP_230233285.1 NZ_CP087584:c4441666-4440953 [Providencia rettgeri]
VTLFAQVLGLISLNDVPHSFILNVGEIKALAVERFDRKYSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNY
LLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFIEPEGCYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRE
MKYNIEQIFPRHFFATAKEVGFDRTEMEKILIEFDEQMESVITKVREQLPTNFPKHIADSILSGLHHKAARLKKGWD

Download         Length: 714 bp

>T225597 NZ_CP121201:781175-782038 [Streptococcus pluranimalium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAGTGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9829.05 Da        Isoelectric Point: 10.0521

>AT225597 WP_210847063.1 NZ_CP087584:c4441969-4441706 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSNSN
SGWKEEW

Download         Length: 264 bp

>AT225597 NZ_CP121201:780901-781173 [Streptococcus pluranimalium]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References