Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1512576..1513233 Replicon chromosome
Accession NZ_CP087584
Organism Providencia rettgeri strain L1

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag LMY39_RS06470 Protein ID WP_042845040.1
Coordinates 1512823..1513233 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag LMY39_RS06465 Protein ID WP_042845042.1
Coordinates 1512576..1512842 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMY39_RS06450 (LMY39_06450) 1509654..1510544 - 891 WP_230233402.1 hypothetical protein -
LMY39_RS06455 (LMY39_06455) 1510705..1511325 - 621 WP_129466208.1 HD domain-containing protein -
LMY39_RS06460 (LMY39_06460) 1511337..1512326 - 990 WP_129466207.1 tRNA-modifying protein YgfZ -
LMY39_RS06465 (LMY39_06465) 1512576..1512842 + 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
LMY39_RS06470 (LMY39_06470) 1512823..1513233 + 411 WP_042845040.1 protein YgfX Toxin
LMY39_RS06475 (LMY39_06475) 1513287..1513805 - 519 WP_042845038.1 flavodoxin FldB -
LMY39_RS06480 (LMY39_06480) 1513923..1514825 + 903 WP_131680648.1 site-specific tyrosine recombinase XerD -
LMY39_RS06485 (LMY39_06485) 1514847..1515551 + 705 WP_042845413.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMY39_RS06490 (LMY39_06490) 1515561..1517294 + 1734 WP_129466205.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T225594 WP_042845040.1 NZ_CP087584:1512823-1513233 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T225594 NZ_CP121199:c4706030-4705656 [Escherichia coli]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATCGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCTCT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCAAAAAAATATGATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTA
AGGCAGGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAACTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTCGTCACACCCTATGAGCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT225594 WP_042845042.1 NZ_CP087584:1512576-1512842 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT225594 NZ_CP121199:c4706272-4706030 [Escherichia coli]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCTGTAGATCAATATCTGGAAAATCAATCGAAAACGA
CAATATCCAGTGCTTTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References