Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 880813..881459 Replicon chromosome
Accession NZ_CP087584
Organism Providencia rettgeri strain L1

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag LMY39_RS03755 Protein ID WP_042846891.1
Coordinates 880813..881016 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag LMY39_RS03760 Protein ID WP_042846890.1
Coordinates 881091..881459 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMY39_RS03730 (LMY39_03730) 876892..877230 + 339 WP_042846895.1 P-II family nitrogen regulator -
LMY39_RS03735 (LMY39_03735) 877280..878524 + 1245 WP_230233526.1 ammonium transporter AmtB -
LMY39_RS03740 (LMY39_03740) 878665..879531 - 867 WP_129466854.1 acyl-CoA thioesterase II -
LMY39_RS03745 (LMY39_03745) 879771..880229 + 459 WP_042846892.1 YbaY family lipoprotein -
LMY39_RS03755 (LMY39_03755) 880813..881016 - 204 WP_042846891.1 HHA domain-containing protein Toxin
LMY39_RS03760 (LMY39_03760) 881091..881459 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
LMY39_RS03765 (LMY39_03765) 881989..883359 - 1371 WP_166685881.1 murein transglycosylase D -
LMY39_RS03770 (LMY39_03770) 883441..884193 - 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
LMY39_RS03775 (LMY39_03775) 884227..884961 + 735 WP_042846887.1 methyltransferase domain-containing protein -
LMY39_RS03780 (LMY39_03780) 884958..885428 - 471 WP_042846886.1 ribonuclease HI -
LMY39_RS03785 (LMY39_03785) 885483..886244 + 762 WP_042846885.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T225593 WP_042846891.1 NZ_CP087584:c881016-880813 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T225593 NZ_CP121199:c4391559-4391386 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT225593 WP_042846890.1 NZ_CP087584:c881459-881091 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT225593 NZ_CP121199:c4391883-4391587 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References