22559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 268602..269197 Replicon chromosome
Accession NC_010086
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name chpB Uniprot ID A0A0H3KX85
Locus tag BMUL_RS17100 Protein ID WP_012216340.1
Coordinates 268602..268952 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0H3KPL3
Locus tag BMUL_RS17105 Protein ID WP_012216341.1
Coordinates 268946..269197 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMUL_RS17090 263692..266877 + 3186 WP_006412982.1 multidrug efflux RND transporter permease subunit CeoB -
BMUL_RS17095 266888..268423 + 1536 WP_012468059.1 multidrug efflux transporter outer membrane subunit OpcM -
BMUL_RS17100 268602..268952 - 351 WP_012216340.1 type II toxin-antitoxin system ChpB family toxin Toxin
BMUL_RS17105 268946..269197 - 252 WP_012216341.1 PbsX family transcriptional regulator Antitoxin
BMUL_RS17110 269325..270818 - 1494 WP_012468058.1 M81 family metallopeptidase -
BMUL_RS17115 270918..272222 - 1305 WP_012216343.1 MFS transporter -
BMUL_RS17120 272364..273335 + 972 WP_012216344.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12412.41 Da        Isoelectric Point: 8.8909

>T22559 WP_012216340.1 NC_010086:c268952-268602 [Burkholderia multivorans ATCC 17616]
MVKRVKFERGDIVRVSPNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMIRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T22559 NC_010086:c268952-268602 [Burkholderia multivorans ATCC 17616]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCCGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGATTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9035.46 Da        Isoelectric Point: 7.9813

>AT22559 WP_012216341.1 NC_010086:c269197-268946 [Burkholderia multivorans ATCC 17616]
MELKIQKWGNSAAVRLPSVLLEQIKATVGSSLSADVRPDGVLLTPARRKYSLDELVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT22559 NC_010086:c269197-268946 [Burkholderia multivorans ATCC 17616]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGTGCGGCGGTTCGCTTGCCCAGCGTTCTGCTCGAACAGATCAAAGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
AGCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGGGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KX85

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KPL3

References