Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2552237..2553825 Replicon chromosome
Accession NZ_CP087580
Organism Klebsiella quasipneumoniae strain OSUCMP263AKPC

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag LO541_RS12400 Protein ID WP_017900381.1
Coordinates 2552237..2553559 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag LO541_RS12405 Protein ID WP_004205921.1
Coordinates 2553559..2553825 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO541_RS12365 (2547319) 2547319..2547537 + 219 WP_002904808.1 ParD-like family protein -
LO541_RS12370 (2547518) 2547518..2548300 + 783 WP_064183715.1 type I methionyl aminopeptidase -
LO541_RS12375 (2548569) 2548569..2549684 + 1116 WP_169319390.1 serine hydrolase domain-containing protein -
LO541_RS12380 (2549671) 2549671..2550015 + 345 WP_004205915.1 hypothetical protein -
LO541_RS12385 (2550044) 2550044..2550577 + 534 WP_087833295.1 DUF2975 domain-containing protein -
LO541_RS12390 (2550580) 2550580..2550786 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
LO541_RS12395 (2550928) 2550928..2552220 + 1293 WP_130939004.1 glycoside hydrolase family 10 protein -
LO541_RS12400 (2552237) 2552237..2553559 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
LO541_RS12405 (2553559) 2553559..2553825 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LO541_RS12410 (2554108) 2554108..2554434 - 327 WP_106939109.1 hydroxyisourate hydrolase -
LO541_RS12415 (2554431) 2554431..2554931 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LO541_RS12420 (2554909) 2554909..2556288 - 1380 WP_023318211.1 nucleobase:cation symporter-2 family protein -
LO541_RS12425 (2556634) 2556634..2557788 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
LO541_RS12430 (2557769) 2557769..2558692 - 924 WP_106939111.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T225589 WP_017900381.1 NZ_CP087580:c2553559-2552237 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

>T225589 NZ_CP121199:3678620-3679162 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT225589 WP_004205921.1 NZ_CP087580:c2553825-2553559 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT225589 NZ_CP121199:3678325-3678636 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References