Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 836654..837311 Replicon chromosome
Accession NZ_CP087580
Organism Klebsiella quasipneumoniae strain OSUCMP263AKPC

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LO541_RS04105 Protein ID WP_004205323.1
Coordinates 836901..837311 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LO541_RS04100 Protein ID WP_002916312.1
Coordinates 836654..836920 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO541_RS04075 (831810) 831810..833243 - 1434 WP_230259419.1 6-phospho-beta-glucosidase -
LO541_RS04080 (833362) 833362..834090 - 729 WP_169319689.1 MurR/RpiR family transcriptional regulator -
LO541_RS04085 (834141) 834141..834452 + 312 WP_106938698.1 N(4)-acetylcytidine aminohydrolase -
LO541_RS04090 (834615) 834615..835274 + 660 WP_057212985.1 hemolysin III family protein -
LO541_RS04095 (835425) 835425..836408 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
LO541_RS04100 (836654) 836654..836920 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LO541_RS04105 (836901) 836901..837311 + 411 WP_004205323.1 protein YgfX Toxin
LO541_RS04110 (837318) 837318..837839 - 522 WP_169319584.1 flavodoxin FldB -
LO541_RS04115 (837940) 837940..838836 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LO541_RS04120 (838859) 838859..839572 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LO541_RS04125 (839578) 839578..841311 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T225580 WP_004205323.1 NZ_CP087580:836901-837311 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T225580 NZ_CP087580:836901-837311 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225580 WP_002916312.1 NZ_CP087580:836654-836920 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225580 NZ_CP087580:836654-836920 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References