Detailed information of TA system TA022558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1023909..1024609
• Replicon: chromosome
• Accession: NC_010084
• Organism: Burkholderia multivorans ATCC 17616

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: BMUL_RS04745
• Protein ID: WP_044055262.1
• Coordinates: 1024232..1024609 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: BMUL_RS04740
• Protein ID: WP_012212958.1
• Coordinates: 1023909..1024232 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMUL_RS04720	1019257..1020717	+	1461	WP_012212954.1	PLP-dependent aminotransferase family protein	-
BMUL_RS04725	1020877..1022775	+	1899	WP_012212955.1	molecular chaperone HtpG	-
BMUL_RS04730	1022784..1023398	+	615	WP_012212956.1	chorismate lyase	-
BMUL_RS04735	1023395..1023886	+	492	WP_012467675.1	DNA-deoxyinosine glycosylase	-
BMUL_RS04740	1023909..1024232	-	324	WP_012212958.1	helix-turn-helix domain-containing protein	Antitoxin
BMUL_RS04745	1024232..1024609	-	378	WP_044055262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BMUL_RS35180	1024582..1024770	+	189	WP_172641365.1	hypothetical protein	-
BMUL_RS04750	1025139..1025393	-	255	WP_012212960.1	hypothetical protein	-
BMUL_RS04755	1025621..1026538	+	918	WP_012212961.1	spermidine synthase	-
BMUL_RS04760	1026735..1026968	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
BMUL_RS04765	1026965..1028515	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
BMUL_RS04770	1028619..1029068	-	450	WP_006413500.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13703.75 Da
• Isoelectric Point: 9.7870

>T22558 WP_044055262.1 NC_010084:c1024609-1024232 [Burkholderia multivorans ATCC 17616]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTRGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T22558 NC_010084:c1024609-1024232 [Burkholderia multivorans ATCC 17616]
ATGGGTATAAATTCGTCGATGGTTCCATACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAGGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCTCAGACGAGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11842.78 Da
• Isoelectric Point: 8.0686

>AT22558 WP_012212958.1 NC_010084:c1024232-1023909 [Burkholderia multivorans ATCC 17616]
MIEIERGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT22558 NC_010084:c1024232-1023909 [Burkholderia multivorans ATCC 17616]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCGGCCAAGATCGCGGAGATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCGCGGTTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGACGCGATGTCCAGATCGTCGTAGGACCGGACCGTCATACGGAAGCCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA