Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1211860..1212549 Replicon chromosome
Accession NZ_CP087578
Organism Escherichia coli strain OSUCMP42NDM

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KUA31_RS06090 Protein ID WP_001460496.1
Coordinates 1211860..1212198 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KUA31_RS06095 Protein ID WP_001460495.1
Coordinates 1212223..1212549 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUA31_RS06070 (1206950) 1206950..1209148 + 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
KUA31_RS06075 (1209158) 1209158..1210114 + 957 WP_000121330.1 molybdenum cofactor insertion chaperone PaoD -
KUA31_RS06080 (1210165) 1210165..1210503 + 339 Protein_1096 LysR substrate-binding domain-containing protein -
KUA31_RS06085 (1210862) 1210862..1211638 - 777 WP_230282996.1 hypothetical protein -
KUA31_RS06090 (1211860) 1211860..1212198 - 339 WP_001460496.1 TA system toxin CbtA family protein Toxin
KUA31_RS06095 (1212223) 1212223..1212549 - 327 WP_001460495.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KUA31_RS06100 (1212592) 1212592..1213071 - 480 WP_001460494.1 DNA repair protein RadC -
KUA31_RS06105 (1213084) 1213084..1213548 - 465 WP_001460493.1 antirestriction protein -
KUA31_RS06110 (1213609) 1213609..1214427 - 819 WP_230282997.1 DUF932 domain-containing protein -
KUA31_RS06115 (1214890) 1214890..1215513 + 624 WP_125291396.1 inovirus Gp2 family protein -
KUA31_RS06120 (1215632) 1215632..1215847 + 216 WP_001461982.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 1186416..1226495 40079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12771.67 Da        Isoelectric Point: 8.5253

>T225551 WP_001460496.1 NZ_CP087578:c1212198-1211860 [Escherichia coli]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQSHHPSAR

Download         Length: 339 bp

>T225551 NZ_CP121160:1501610-1501864 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12552.27 Da        Isoelectric Point: 6.3682

>AT225551 WP_001460495.1 NZ_CP087578:c1212549-1212223 [Escherichia coli]
MEKHDTPEWGLRCDVMPRFSARLVQKNNRLHYLADRAGITGAFKEEECHQLNSAFPHFIEQMELMLLSGELNPRHAHRVT
LYHDELTCEADTLGSCGYVYMAIYPTQR

Download         Length: 327 bp

>AT225551 NZ_CP121160:1501351-1501617 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References