Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 567079..567601 | Replicon | chromosome |
| Accession | NZ_CP087578 | ||
| Organism | Escherichia coli strain OSUCMP42NDM | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A829L6G8 |
| Locus tag | KUA31_RS03115 | Protein ID | WP_001105433.1 |
| Coordinates | 567311..567601 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SC69 |
| Locus tag | KUA31_RS03110 | Protein ID | WP_000212715.1 |
| Coordinates | 567079..567321 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUA31_RS03090 (562791) | 562791..564164 | + | 1374 | WP_001219795.1 | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase | - |
| KUA31_RS03095 (564320) | 564320..564871 | - | 552 | WP_000166270.1 | ribosome biogenesis factor YjgA | - |
| KUA31_RS03100 (564965) | 564965..566317 | + | 1353 | WP_001162171.1 | metalloprotease PmbA | - |
| KUA31_RS03105 (566501) | 566501..566887 | + | 387 | WP_001232246.1 | cytochrome b562 | - |
| KUA31_RS03110 (567079) | 567079..567321 | + | 243 | WP_000212715.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KUA31_RS03115 (567311) | 567311..567601 | + | 291 | WP_001105433.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KUA31_RS03120 (567602) | 567602..568066 | - | 465 | WP_001106233.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
| KUA31_RS03125 (568224) | 568224..570362 | - | 2139 | WP_000187799.1 | anaerobic ribonucleoside-triphosphate reductase | - |
| KUA31_RS03130 (570756) | 570756..572411 | - | 1656 | WP_001392998.1 | alpha,alpha-phosphotrehalase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11367.23 Da Isoelectric Point: 10.0238
>T225547 WP_001105433.1 NZ_CP087578:567311-567601 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE
Download Length: 291 bp
>T225547 NZ_CP121159:1119724-1120500 [Streptococcus agalactiae]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9125.56 Da Isoelectric Point: 5.1369
>AT225547 WP_000212715.1 NZ_CP087578:567079-567321 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL
Download Length: 243 bp
>AT225547 NZ_CP121159:1119248-1119724 [Streptococcus agalactiae]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829L6G8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9H4B3 |