Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1425776..1426577 Replicon chromosome
Accession NZ_CP087570
Organism Escherichia coli strain 114

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag LOS76_RS06790 Protein ID WP_001094437.1
Coordinates 1425776..1426153 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag LOS76_RS06795 Protein ID WP_001390338.1
Coordinates 1426200..1426577 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOS76_RS06760 (1421133) 1421133..1422056 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
LOS76_RS06765 (1422167) 1422167..1423351 - 1185 WP_001172877.1 sugar efflux transporter -
LOS76_RS06770 (1423781) 1423781..1423909 - 129 Protein_1313 RhuM family protein -
LOS76_RS06775 (1424144) 1424144..1424989 - 846 WP_001274561.1 DUF4942 domain-containing protein -
LOS76_RS06780 (1425074) 1425074..1425271 - 198 WP_000772032.1 DUF957 domain-containing protein -
LOS76_RS06785 (1425291) 1425291..1425779 - 489 WP_000761716.1 DUF5983 family protein -
LOS76_RS06790 (1425776) 1425776..1426153 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
LOS76_RS06795 (1426200) 1426200..1426577 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LOS76_RS06800 (1426740) 1426740..1426961 - 222 WP_000692345.1 DUF987 domain-containing protein -
LOS76_RS06805 (1427024) 1427024..1427500 - 477 WP_001186747.1 RadC family protein -
LOS76_RS06810 (1427516) 1427516..1427686 - 171 Protein_1321 antirestriction protein -
LOS76_RS06815 (1427688) 1427688..1428452 - 765 Protein_1322 ESPR-type extended signal peptide-containing protein -
LOS76_RS06820 (1428824) 1428824..1429588 - 765 WP_162869019.1 GTPase family protein -
LOS76_RS06825 (1429978) 1429978..1430189 + 212 Protein_1324 hemolysin expression modulator Hha -
LOS76_RS06830 (1430532) 1430532..1430729 - 198 WP_001545803.1 hypothetical protein -
LOS76_RS06835 (1430933) 1430933..1431502 + 570 WP_000148641.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T225511 WP_001094437.1 NZ_CP087570:c1426153-1425776 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T225511 NZ_CP121155:c2154008-2153901 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT225511 WP_001390338.1 NZ_CP087570:c1426577-1426200 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT225511 NZ_CP121155:2154056-2154122 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References