Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 3565203..3566128 | Replicon | chromosome |
| Accession | NZ_CP087564 | ||
| Organism | Escherichia coli strain CM2010-0578/1 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | LOF66_RS17755 | Protein ID | WP_014640052.1 |
| Coordinates | 3565742..3566128 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | LOF66_RS17750 | Protein ID | WP_001339382.1 |
| Coordinates | 3565203..3565712 (+) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOF66_RS17715 (3560228) | 3560228..3560836 | + | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| LOF66_RS17720 (3560909) | 3560909..3562234 | + | 1326 | WP_001326646.1 | MATE family efflux transporter DinF | - |
| LOF66_RS17725 (3562350) | 3562350..3562559 | + | 210 | WP_001030593.1 | CsbD family protein | - |
| LOF66_RS17730 (3562601) | 3562601..3563116 | - | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| LOF66_RS17735 (3563434) | 3563434..3563688 | + | 255 | WP_000912571.1 | protein YjbL | - |
| LOF66_RS17740 (3563712) | 3563712..3564419 | + | 708 | WP_001311303.1 | DUF2713 domain-containing protein | - |
| LOF66_RS17745 (3564782) | 3564782..3564886 | + | 105 | Protein_3461 | tRNA-dihydrouridine synthase | - |
| LOF66_RS17750 (3565203) | 3565203..3565712 | + | 510 | WP_001339382.1 | Panacea domain-containing protein | Antitoxin |
| LOF66_RS17755 (3565742) | 3565742..3566128 | + | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| LOF66_RS17760 (3566168) | 3566168..3566341 | + | 174 | WP_000390072.1 | hypothetical protein | - |
| LOF66_RS17765 (3566389) | 3566389..3566670 | - | 282 | WP_001093917.1 | pyocin activator PrtN family protein | - |
| LOF66_RS17770 (3566707) | 3566707..3567279 | - | 573 | WP_001061348.1 | 3'-5' exonuclease | - |
| LOF66_RS17775 (3567279) | 3567279..3568088 | - | 810 | WP_000206745.1 | hypothetical protein | - |
| LOF66_RS17780 (3568088) | 3568088..3568450 | - | 363 | WP_001242704.1 | hypothetical protein | - |
| LOF66_RS17785 (3568441) | 3568441..3568977 | - | 537 | WP_000008236.1 | 5'-deoxynucleotidase | - |
| LOF66_RS17790 (3569511) | 3569511..3570164 | - | 654 | WP_000981537.1 | S24 family peptidase | - |
| LOF66_RS17795 (3570260) | 3570260..3570457 | + | 198 | WP_001231956.1 | Cro/CI family transcriptional regulator | - |
| LOF66_RS17800 (3570485) | 3570485..3571069 | + | 585 | WP_000514174.1 | YmfL family putative regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3560228..3606898 | 46670 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T225492 WP_014640052.1 NZ_CP087564:3565742-3566128 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
>T225492 NZ_CP121153:c3635013-3634711 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 170 a.a. Molecular weight: 19576.29 Da Isoelectric Point: 5.3338
>AT225492 WP_001339382.1 NZ_CP087564:3565203-3565712 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
>AT225492 NZ_CP121153:c3634675-3634334 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|