Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4048378..4048928 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LOZ86_RS18240 Protein ID WP_039513069.1
Coordinates 4048620..4048928 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LOZ86_RS18235 Protein ID WP_052237773.1
Coordinates 4048378..4048617 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS18210 (LOZ86_18210) 4043728..4044039 - 312 WP_103160829.1 AzlD domain-containing protein -
LOZ86_RS18215 (LOZ86_18215) 4044036..4044770 - 735 WP_103160830.1 AzlC family ABC transporter permease -
LOZ86_RS18220 (LOZ86_18220) 4044998..4045834 - 837 WP_039513064.1 AraC family transcriptional regulator -
LOZ86_RS18225 (LOZ86_18225) 4046053..4047672 - 1620 WP_039513065.1 methyl-accepting chemotaxis protein -
LOZ86_RS18230 (LOZ86_18230) 4048118..4048303 - 186 WP_111779007.1 hypothetical protein -
LOZ86_RS18235 (LOZ86_18235) 4048378..4048617 + 240 WP_052237773.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LOZ86_RS18240 (LOZ86_18240) 4048620..4048928 + 309 WP_039513069.1 CcdB family protein Toxin
LOZ86_RS18245 (LOZ86_18245) 4049071..4049235 - 165 WP_039513071.1 glucose uptake inhibitor SgrT -
LOZ86_RS18250 (LOZ86_18250) 4049326..4050984 + 1659 WP_111779006.1 HTH-type transcriptional regulator SgrR -
LOZ86_RS18255 (LOZ86_18255) 4051202..4052182 + 981 WP_146752746.1 thiamine ABC transporter substrate binding subunit -
LOZ86_RS18260 (LOZ86_18260) 4052158..4053765 + 1608 WP_230242569.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11766.60 Da        Isoelectric Point: 9.3356

>T225464 WP_039513069.1 NZ_CP087392:4048620-4048928 [Pectobacterium parvum]
MQYKVYRNNGNSNSYPYLLNVQSDIIGELHTRLVIPLFPLNKVARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQMYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T225464 NZ_CP121151:3043194-3043301 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9068.43 Da        Isoelectric Point: 10.0137

>AT225464 WP_052237773.1 NZ_CP087392:4048378-4048617 [Pectobacterium parvum]
MPVTSIRHKKTVSVTLEPMLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT225464 NZ_CP121151:c3043141-3043080 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References