Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3677265..3677857 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOZ86_RS16500 Protein ID WP_116238280.1
Coordinates 3677265..3677519 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOZ86_RS16505 Protein ID WP_039288288.1
Coordinates 3677516..3677857 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS16470 (LOZ86_16470) 3672281..3672481 + 201 WP_230242378.1 hypothetical protein -
LOZ86_RS16475 (LOZ86_16475) 3673199..3673414 + 216 WP_230242379.1 hypothetical protein -
LOZ86_RS16480 (LOZ86_16480) 3673598..3674806 - 1209 WP_230242335.1 IS256 family transposase -
LOZ86_RS16485 (LOZ86_16485) 3674892..3675605 + 714 WP_230242381.1 hypothetical protein -
LOZ86_RS16490 (LOZ86_16490) 3675911..3676204 - 294 WP_230242397.1 Arc family DNA-binding protein -
LOZ86_RS16495 (LOZ86_16495) 3676501..3677178 + 678 WP_230242399.1 ORF6N domain-containing protein -
LOZ86_RS16500 (LOZ86_16500) 3677265..3677519 + 255 WP_116238280.1 type II toxin-antitoxin system HicA family toxin Toxin
LOZ86_RS16505 (LOZ86_16505) 3677516..3677857 + 342 WP_039288288.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOZ86_RS16510 (LOZ86_16510) 3677890..3678909 - 1020 WP_230242401.1 phage portal protein -
LOZ86_RS16515 (LOZ86_16515) 3678906..3680675 - 1770 WP_230242402.1 terminase ATPase subunit family protein -
LOZ86_RS16520 (LOZ86_16520) 3680815..3681670 + 856 Protein_3218 GPO family capsid scaffolding protein -
LOZ86_RS16525 (LOZ86_16525) 3681721..3682848 + 1128 WP_230242416.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 3662970..3708255 45285
- flank IS/Tn - - 3673598..3674806 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9498.89 Da        Isoelectric Point: 11.1983

>T225462 WP_116238280.1 NZ_CP087392:3677265-3677519 [Pectobacterium parvum]
MNKRHQKTLSDVFSRPVSGSIKWSDIESLFIALGAEVHEREGSRVAVLLNGEKRIFHRPHPRPTTDKGAVNSIRIWLDSL
GVRP

Download         Length: 255 bp

>T225462 NZ_CP121151:c2830428-2830252 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12370.87 Da        Isoelectric Point: 4.4630

>AT225462 WP_039288288.1 NZ_CP087392:3677516-3677857 [Pectobacterium parvum]
MINTLQIDGHTAVIAFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGATSLAVFLDECRHDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQANGVSINELLNEGVDLVIERHS

Download         Length: 342 bp

>AT225462 NZ_CP121151:c2830206-2829790 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References