Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3454673..3455298 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag LOZ86_RS15500 Protein ID WP_005976087.1
Coordinates 3455095..3455298 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6P1S9D7
Locus tag LOZ86_RS15495 Protein ID WP_039487867.1
Coordinates 3454673..3455041 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS15480 (LOZ86_15480) 3450351..3453479 + 3129 WP_039487869.1 efflux RND transporter permease subunit -
LOZ86_RS15485 (LOZ86_15485) 3453666..3453914 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
LOZ86_RS15490 (LOZ86_15490) 3453932..3454075 + 144 WP_072012464.1 type B 50S ribosomal protein L36 -
LOZ86_RS15495 (LOZ86_15495) 3454673..3455041 + 369 WP_039487867.1 Hha toxicity modulator TomB Antitoxin
LOZ86_RS15500 (LOZ86_15500) 3455095..3455298 + 204 WP_005976087.1 HHA domain-containing protein Toxin
LOZ86_RS15510 (LOZ86_15510) 3456046..3456366 + 321 WP_010282239.1 MGMT family protein -
LOZ86_RS15515 (LOZ86_15515) 3456386..3456967 - 582 WP_039485508.1 YbaY family lipoprotein -
LOZ86_RS15520 (LOZ86_15520) 3457179..3458042 + 864 WP_039485505.1 acyl-CoA thioesterase II -
LOZ86_RS15525 (LOZ86_15525) 3458099..3459420 - 1322 Protein_3027 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T225461 WP_005976087.1 NZ_CP087392:3455095-3455298 [Pectobacterium parvum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T225461 NZ_CP121151:2712116-2713438 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCGCCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14013.72 Da        Isoelectric Point: 4.4776

>AT225461 WP_039487867.1 NZ_CP087392:3454673-3455041 [Pectobacterium parvum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRHWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT225461 NZ_CP121151:2711850-2712116 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S9D7

References